Recombinant Human COL1A2, His-tagged

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Recombinant Human COL1A2, His-tagged

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Cat.No. : COL1A2-116H?
Product Overview : Recombinant Human COL1A2 was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.
Description : This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : 1017-1366aa
Storage : The protein is stored in PBS bu?er at -20 oC. Repeated freezethaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : COL1A2?collagen, type I, alpha 2 [?Homo sapiens?(human) ]
Official Symbol : COL1A2
Synonyms : COL1A2; OI4; collagen, type I, alpha 2; collagen alpha-2(I) chain; type I procollagen; alpha 2(I)-collagen; alpha-2 type I collagen; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain
Gene ID : 1278
mRNA Refseq : NM_000089
Protein Refseq : NP_000080
MIM : 120160
UniProt ID : P08123
Chromosome Location : 7q22.1
Pathway : Binding and Uptake of Ligands by Scavenger Receptors; ECM-receptor interaction; Focal Adhesion
Function : extracellular matrix structural constituent; identical protein binding; metal ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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