Recombinant Human PF4V1, His-tagged

• Cat.No.: PF4V1-162H
• Product Overview: PF4V1, 31-104aa, Human, His tag, E.coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 31-104aa
• Description: PF4V1 belongs to the intercrine alpha (chemokine CxC) family. It is a inhibitor of angiogenesis and inhibitor of endothelial cell chemotaxis(in vitro). Binding to heparin is much weaker than in the close homolog PF4/CXCL4. Recombinant human PF4V1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 1mM DTT.
• Molecular Mass: 10.6 kDa (97aa) confirmed by MALDI-TOF
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSFARAEAE EDGDLQCLCV KTTSQVRPRH ITSLEVIKAG PHCPTAQLIA TLKNGRKICL DLQALLYKKI IKEHLES
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PF4V1 platelet factor 4 variant 1 [ Homo sapiens ]
• Official Symbol: PF4V1
• Synonyms: PF4V1; platelet factor 4 variant 1; platelet factor 4 variant; CXCL4L1; CXCL4V1; SCYB4V1; PF4alt; PF4var1; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like); PF4A; PF4-ALT
• Gene ID: 5197
• mRNA Refseq: NM_002620
• Protein Refseq: NP_002611
• MIM: 173461
• UniProt ID: P10720
• Chromosome Location: 4q12-q21
• Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Common Pathway, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem
• Function: chemokine activity; heparin binding