Active Native acyl-CoA oxidase
Cat.No. : | ACOD-35 |
Product Overview : | Native acyl-CoA oxidase (EC 1.3.3.6) was purified from Arthrobacter sp.. |
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Description : | In enzymology, an acyl-CoA oxidase (EC 1.3.3.6) is an enzyme that catalyzes the chemical reactionacyl-CoA + O2 \rightleftharpoons trans-2,3-dehydroacyl-CoA + H2O2Thus, the two substrates of this enzyme are acyl-CoA and O2, whereas its two products are trans-2,3-dehydroacyl-CoA and H2O2. |
Source : | Arthrobacter sp. |
Species : | Arthrobacter sp. |
Form : | Yellowish lyophilized powder. |
Bio-activity : | 20~40 U/mg |
Storage : | Store in tightly closed containers, desiccated, protected from light, at -20oC. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Ask a questionACOD is studied through a variety of biochemical and biophysical techniques, including enzymatic assays, X-ray crystallography, and nuclear magnetic resonance (NMR) spectroscopy.
The main benefit of ACOD is its role in the generation of energy (ATP) through the citric acid cycle. It also plays a role in the synthesis of amino acids and heme, and has been implicated in the regulation of iron metabolism.
Mitochondrial dysfunction can result in a reduction in the activity of the citric acid cycle, including ACOD. This can lead to a decrease in the production of ATP and an increase in the production of reactive oxygen species, which can contribute to a variety of diseases.
ACOD has been shown to play a role in iron metabolism by regulating the activity of iron regulatory proteins (IRPs). IRPs control the expression of genes involved in iron uptake, storage, and utilization.
Since ACOD is involved in energy production, a deficiency of this enzyme can result in a reduced ability to generate ATP, which can lead to cellular dysfunction and diseases like hereditary sideroblastic anemia.
ACOD is a homodimeric enzyme, with each monomer consisting of a large and a small domain connected by a flexible linker.
ACOD activity can be regulated by a number of factors, including substrate availability, pH, and the presence of other compounds that can affect enzyme activity.
ACOD has not been studied as a therapeutic target. However, targeting enzymes involved in the citric acid cycle has been investigated as a potential treatment for cancer.
ACOD is found in the cytoplasm of most eukaryotic cells, where it functions in the citric acid cycle.
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