Recombinant Human PLA2G1B, His-tagged

• Cat.No.: PLA2G1B-1751H
• Product Overview: Recombinant Human PLA2G1B protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-70aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: PLA2G1B phospholipase A2, group IB (pancreas) [ Homo sapiens ]
• Official Symbol: PLA2G1B
• Synonyms: PLA2G1B; phospholipase A2, group IB (pancreas); PLA2, PLA2A, PPLA2; phospholipase A2; group IB phospholipase A2; phosphatidylcholine 2-acylhydrolase 1B; PLA2; PLA2A; PPLA2; MGC119834; MGC119835
• Gene ID: 5319
• mRNA Refseq: NM_000928
• Protein Refseq: NP_000919
• MIM: 172410
• UniProt ID: P04054
• Chromosome Location: 12q23-qter
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem; Fat digestion and absorption, organism-specific biosystem; Fat digestion and absorption, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem
• Function: bile acid binding; calcium ion binding; calcium ion binding; calcium-dependent phospholipase A2 activity; cell surface binding; hydrolase activity; phospholipase A2 activity; phospholipase A2 activity; receptor binding; receptor binding

Reviews

03/12/2020

Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.

10/16/2017

The PLA2G1B protein comes highly recommended for its exceptional performance in various research applications.

01/09/2016

Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.

Q&As

How is PLA2G1B involved in cardiovascular diseases?

PLA2G1B is associated with atherosclerosis and other cardiovascular conditions due to its involvement in lipid metabolism and inflammation.

Are there potential neuroprotective effects of modulating PLA2G1B activity?

Modulating PLA2G1B activity could be explored for potential neuroprotective effects, given its involvement in processes related to neuroinflammation.

In what diseases is PLA2G1B dysregulation observed?

Dysregulation of PLA2G1B has been linked to inflammatory disorders, cardiovascular diseases, and certain cancers.

Can PLA2G1B be a therapeutic target for inflammatory conditions?

Yes, targeting PLA2G1B may be a potential therapeutic strategy for inflammatory diseases, as it plays a role in the production of inflammatory mediators.

Can PLA2G1B inhibitors be used for treating cancer?

Inhibiting PLA2G1B may be explored as a therapeutic approach in cancer treatment by disrupting lipid metabolism and inhibiting cancer cell proliferation.