Recombinant Human MSH6, His-tagged
Cat.No. : | MSH6-2413H |
Product Overview : | Recombinant Human MSH6 as expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Protein length : | False |
AA Sequence : | 1-400aa |
Storage : | The protein is stored in PBS buffer at -20 oC. Repeated freeze-thaw cycles should be avoided. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Gene Name : | MSH6 mutS homolog 6 [ Homo sapiens (human) ] |
Official Symbol : | MSH6 |
Synonyms : | MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; mutS homolog 6; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein |
Gene ID : | 2956 |
mRNA Refseq : | NM_000179 |
Protein Refseq : | NP_000170 |
MIM : | 600678 |
UniProt ID : | P52701 |
Chromosome Location : | 2p16 |
Pathway : | BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Mismatch repair |
Function : | contributes_to ADP binding; contributes_to ATPase activity; contributes_to MutLalpha complex binding |
Products Types
◆ Recombinant Protein | ||
MSH6-2693R | Recombinant Rhesus Macaque MSH6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSH6-03H | Recombinant Human MSH6 Protein, N-His tagged | +Inquiry |
MSH6-5740M | Recombinant Mouse MSH6 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSH6-4225H | Recombinant Human MSH6 Protein (Met1-Glu400), N-His tagged | +Inquiry |
MSH6-2873R | Recombinant Rhesus monkey MSH6 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MSH6-4117HCL | Recombinant Human MSH6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMSH6 modulates cell cycle and apoptosis, ensuring cells with DNA damage do not proliferate.
Mutations in MSH6 increase the risk of various cancers, due to impaired DNA repair mechanisms.
MSH6 deficiency can lead to HNPCC by allowing accumulation of DNA replication errors.
MSH6 is crucial in DNA mismatch repair, helping correct replication errors to maintain DNA integrity.
MSH6 plays a vital role in preventing mutations and maintaining genomic stability.
Alterations in MSH6 can affect the response to chemotherapy, potentially impacting treatment outcomes.
MSH6 is involved in the cellular response to DNA damage, facilitating repair to prevent mutations.
Customer Reviews (3)
Write a reviewReliable mass spectrometry analysis, pivotal for advancing our proteomics research.
High-quality protein crystallography services, consistently delivers exceptional results.
Swift and reliable protein sequencing, a key asset for our work.
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