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Recombinant Human MSH6, His-tagged

Cat.No. : MSH6-2413H
Product Overview : Recombinant Human MSH6 as expressed as 6*his-tagged fusion protein by E.Coli and purified by Ni-sepharose.
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  • Gene Information
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Description : This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Source : E. coli
Species : Human
Tag : His
Protein length : False
AA Sequence : 1-400aa
Storage : The protein is stored in PBS buffer at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : MSH6 mutS homolog 6 [ Homo sapiens (human) ]
Official Symbol : MSH6
Synonyms : MSH6; GTBP; HSAP; p160; GTMBP; HNPCC5; mutS homolog 6; DNA mismatch repair protein Msh6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein
Gene ID : 2956
mRNA Refseq : NM_000179
Protein Refseq : NP_000170
MIM : 600678
UniProt ID : P52701
Chromosome Location : 2p16
Pathway : BRCA1-associated genome surveillance complex (BASC); Colorectal cancer; Mismatch repair
Function : contributes_to ADP binding; contributes_to ATPase activity; contributes_to MutLalpha complex binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which MSH6 modulates cell cycle checkpoints and apoptosis? 10/15/2021

MSH6 modulates cell cycle and apoptosis, ensuring cells with DNA damage do not proliferate.

What is the impact of MSH6 mutations on the risk of other types of cancers? 05/02/2021

Mutations in MSH6 increase the risk of various cancers, due to impaired DNA repair mechanisms.

How does MSH6 deficiency contribute to the development of hereditary non-polyposis colorectal cancer (HNPCC)? 02/10/2021

MSH6 deficiency can lead to HNPCC by allowing accumulation of DNA replication errors.

How does MSH6 (MutS Homolog 6) function in the DNA mismatch repair system? 07/10/2020

MSH6 is crucial in DNA mismatch repair, helping correct replication errors to maintain DNA integrity.

What role does MSH6 play in maintaining genomic stability and preventing mutations? 06/19/2020

MSH6 plays a vital role in preventing mutations and maintaining genomic stability.

How do alterations in MSH6 expression or function affect the efficacy of chemotherapy in cancer treatment? 05/06/2018

Alterations in MSH6 can affect the response to chemotherapy, potentially impacting treatment outcomes.

How does MSH6 influence the cellular response to DNA damage and repair processes? 02/09/2018

MSH6 is involved in the cellular response to DNA damage, facilitating repair to prevent mutations.

Customer Reviews (3)

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Reviews
02/01/2020

    Reliable mass spectrometry analysis, pivotal for advancing our proteomics research.

    08/29/2019

      High-quality protein crystallography services, consistently delivers exceptional results.

      02/19/2019

        Swift and reliable protein sequencing, a key asset for our work.

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