||Recombinant Human TSHR was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.
||The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
||The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
||1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.