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Human Telomerase reverse transcriptase peptide

Cat.No.: TERT-560H
Product Overview: It is a synthetic Human Telomerase reverse transcriptase peptide.
Description: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Species: Human
Form: Liquid
Protein length: 550-600
Applications: Blocking
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Concentration: 100 µg at 1 mg/ml
Gene Name: TERT telomerase reverse transcriptase [ Homo sapiens (human) ]
Official Symbol: TERT
Synonyms: TERT; TP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1; telomerase reverse transcriptase; telomerase catalytic subunit; telomerase-associated protein 2; NP_001180305.1; EC 2.7.7.49; NP_937983.2
Gene ID: 7015
mRNA Refseq: NM_001193376
Protein Refseq: NP_001180305
MIM: 187270
UniProt ID: O14746
Chromosome Location: 5p15.33
Pathway: Chromosome Maintenance; Extension of Telomeres; Id Signaling Pathway
Function: metal ion binding; protein homodimerization activity; telomeric DNA binding

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