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Recombinant Human ZEB1, GST-tagged

Cat.No. : ZEB1-3796H
Product Overview : Recombinant Human ZEB1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Source : E.coli
Species : Human
Tag : GST
Protein length : 391-740aa
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ZEB1 zinc finger E-box binding homeobox 1 [ Homo sapiens ]
Official Symbol : ZEB1
Synonyms : ZEB1; zinc finger E-box binding homeobox 1; posterior polymorphous corneal dystrophy 3 , PPCD3, TCF8, transcription factor 8 (represses interleukin 2 expression); zinc finger E-box-binding homeobox 1; AREB6; BZP; NIL 2 A; ZEB; Zfhep; Zfhx1a; negative regulator of IL2; delta-crystallin enhancer binding factor 1; posterior polymorphous corneal dystrophy 3; zinc finger homeodomain enhancer-binding protein; transcription factor 8 (represses interleukin 2 expression); TCF8; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1; MGC133261;
Gene ID : 6935
mRNA Refseq : NM_001128128
Protein Refseq : NP_001121600
MIM : 189909
UniProt ID : P37275
Chromosome Location : 10p11.22
Pathway : Hypertrophy Model, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;
Function : E-box binding; E-box binding; chromatin binding; double-stranded DNA binding; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; transcription

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is there a correlation between ZEB1 expression and patient survival rates in clinical studies? 11/07/2020

Clinical studies have indicated a correlation between high ZEB1 expression and reduced overall survival rates in cancer patients.

Are there any known inhibitors or drugs targeting the ZEB1 protein? 09/25/2020

Some research is focused on developing inhibitors targeting ZEB1 as potential therapeutic agents, although this area is still in the early stages.

How does ZEB1 contribute to the invasion and metastasis of cancer cells? 04/10/2020

ZEB1 promotes the invasion and metastasis of cancer cells by inducing EMT, allowing cells to acquire a more migratory and invasive phenotype.

Can ZEB1 be targeted for personalized medicine approaches in cancer treatment? 01/27/2017

Targeting ZEB1 for personalized medicine approaches is an area of active research, exploring its potential as a specific therapeutic target based on individual patient profiles.

Can the detection of ZEB1 expression levels be used for early cancer diagnosis? 11/15/2016

Emerging evidence suggests that assessing ZEB1 expression levels may have diagnostic potential, especially in identifying early stages of certain cancers.

Customer Reviews (3)

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02/16/2020

    They provide comprehensive assistance, ensuring that any queries or concerns I have regarding the ZEB1 protein are promptly addressed.

    05/29/2018

      One of the standout advantages offered by the manufacturer is their excellent technical support.

      06/24/2016

        They continuously stay up-to-date with the latest scientific advancements and customer feedback, allowing them to refine the ZEB1 protein based on emerging trends.

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