Active Native Human C5
Cat.No. : | C5-10540H |
Product Overview : | Native Human C5 was purified from human serum. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. |
Source : | human serum |
Species : | Human |
Bio-activity : | >100,000 C5H50 units/ mg protein |
Purity : | ≥90% (SDS-PAGE) |
Applications : | Complement C5 is part of the terminal sequence in the complement pathway. In particular, it is cleaved into C5a and C5b which are responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis. |
Stability : | The product ships on dry ice and storage at –70 °C is recommended. Repeated freezing and thawing is not recommended. |
Shipping : | dry ice |
Gene Name : | C5 complement component 5 [ Homo sapiens ] |
Official Symbol : | C5 |
Synonyms : | C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298; |
Gene ID : | 727 |
mRNA Refseq : | NM_001735 |
Protein Refseq : | NP_001726 |
MIM : | 120900 |
UniProt ID : | P01031 |
Chromosome Location : | 9q33-q34 |
Pathway : | Activation of C3 and C5, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; |
Function : | C5a anaphylatoxin chemotactic receptor binding; chemokine activity; endopeptidase inhibitor activity; receptor binding; |
Products Types
◆ Recombinant Protein | ||
C5-348P | Recombinant Pig C5 Protein, His-tagged | +Inquiry |
C5-347R | Recombinant Rat C5 Protein, His-tagged | +Inquiry |
C5-344H | Recombinant Human C5 Protein, His-tagged | +Inquiry |
C5-346R | Recombinant Rat C5 Protein, His-tagged | +Inquiry |
C5-2711M | Recombinant Mouse C5 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
C5-53H | Native Human Complement C5 | +Inquiry |
◆ Lysates | ||
C5-8020HCL | Recombinant Human C5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionYes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.
C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.
In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.
C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.
In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.
Customer Reviews (3)
Write a reviewWhether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.
Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.
Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.
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