Active Recombinant Human SIRT1, His-tagged
Cat.No. : | SIRT1-463H |
Product Overview : | Human sirtuin 1 (aa 2-555) is fused at the N-terminus to a His-tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
Bio-activity : | HDAC activity. |
Molecular Mass : | ~70kDa (SDS-PAGE) |
Endotoxin : | <1EU/μg purified protein (LAL test; Lonza). |
Purity : | ≥95% (SDS-PAGE). |
Stability : | Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°CLong Term Storage: -20°CHandling Advice: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. |
Gene Name : | SIRT1 sirtuin 1 [ Homo sapiens (human) ] |
Official Symbol : | SIRT1 |
Synonyms : | SIRT1; SIR2L1; sirtuin 1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1 |
Gene ID : | 23411 |
mRNA Refseq : | NM_001142498 |
Protein Refseq : | NP_001135970 |
MIM : | 604479 |
UniProt ID : | Q96EB6 |
Chromosome Location : | 10q21.3 |
Pathway : | Amphetamine addiction; Androgen receptor signaling pathway; FoxO signaling pathway |
Function : | HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity |
Products Types
◆ Recombinant Protein | ||
Sirt1-5883M | Recombinant Mouse Sirt1 Protein, Myc/DDK-tagged | +Inquiry |
SIRT1-1165H | Recombinant Human SIRT1 protein(Met193-Ser747), His-tagged | +Inquiry |
SIRT1-113H | Recombinant Human SIRT1 Protein, GST-tagged | +Inquiry |
SIRT1-11H | Recombinant Human SIRT1 Protein, MYC/DDK-tagged | +Inquiry |
SIRT1-100M | Recombinant Mouse SIRT1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
SIRT1-595HCL | Recombinant Human SIRT1 lysate | +Inquiry |
◆ Assay kits | ||
Kit-2025 | SIRT1 FRET-Based Screening Assay Kit | +Inquiry |
Kit-2156 | SIRT1 Inhibitor/Activator Screening Kit | +Inquiry |
Kit-2024 | SIRT1 Direct Fluorescent Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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