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Recombinant Human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative), His-tagged

Cat.No. : APOBEC4-309H
Product Overview : APOBEC4, 1-367aa, Human, His tag, E.coli
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  • Gene Information
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Description : The APOBEC4 is a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in Mrna editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. Recombinant human APOBEC4 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
Molecular Mass : 44.0kDa (390aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMEPIYEE YLANHGTIVK PYYWLSFSLD CSNCPYHIRT GEEARVSLTE FCQIFGFPYG TTFPQTKHLT FYELKTSSGS LVQKGHASSC TGNYIHPESM LFEMNGYLDS AIYNNDSIRH IILYSNNSPC NEANHCCISK MYNFLITYPG ITLSIYFSQL YHTEMDFPAS AWNREALRSL ASLWPRVVLS PISGGIWHSV LHSFISGVSG SHVFQPILTG RALADRHNAY EINAITGVKP YFTDVLLQTK RNPNTKAQEA LESYPLNNAF PGQFFQMPSG QLQPNLPPDL RAPVVFVLVP LRDLPPMHMG QNPNKPRNIV RHLNMPQMSF QETKDLGRLP TGRSVEIVEI TEQFASSKEA DEKKKKKGKK
Purity : >85% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1.0 mg/ml (determined by Bradford assay)
Gene Name : APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) [ Homo sapiens ]
Official Symbol : APOBEC4
Synonyms : APOBEC4; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); C1orf169, chromosome 1 open reading frame 169; putative C->U-editing enzyme APOBEC-4; FLJ25691; MGC26594; RP1 127C7.4; putative C->U-editing enzyme APOBEC-4; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4; C1orf169;
Gene ID : 403314
mRNA Refseq : NM_203454
Protein Refseq : NP_982279
MIM : 609908
UniProt ID : Q8WW27
Chromosome Location : 1q25.3
Function : hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; metal ion binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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Are there any drugs or therapies targeting APOBEC4 currently in development? 03/28/2023

As of now, there are no known drugs or therapies specifically targeting APOBEC4 in development. However, future research may uncover potential therapeutic applications or strategies involving APOBEC4 modulation to treat certain diseases or conditions.

What are the consequences of APOBEC4 deficiency? 03/13/2023

The consequences of APOBEC4 deficiency have not been extensively characterized. As APOBEC4 is primarily expressed in the reproductive tissues, it is possible that deficiencies could impact reproductive processes or fertility. However, further research is necessary to understand the specific consequences of APOBEC4 deficiency.

Are there any known genetic variants or polymorphisms in the APOBEC4 gene? 11/15/2021

Genetic variants and polymorphisms in the APOBEC4 gene have been identified, but their functional significance and association with diseases or traits are not well-characterized. Future studies may help shed light on the relevance of these genetic variations.

How does APOBEC4 differ from other APOBEC family members? 10/13/2021

APOBEC4 differs from other APOBEC family members in terms of tissue expression pattern and substrate specificity. It shows a more restricted expression pattern in specific tissues and has a distinct target specificity compared to other APOBEC proteins.

How is APOBEC4 regulated in the cell? 05/20/2021

The regulation of APOBEC4 is not yet fully understood. However, studies have suggested that its expression may be regulated at the transcriptional level by various factors, including hormones and transcriptional regulators.

Are there any known regulatory factors or networks that control APOBEC4 expression? 04/05/2021

The regulatory factors or networks that control APOBEC4 expression are not well-defined. However, like other genes, APOBEC4 expression may be regulated by various factors, including transcription factors, hormones, and epigenetic modifications. Further research is needed to identify the specific regulators and networks that govern APOBEC4 expression.

Is APOBEC4 involved in the development of cancer? 01/05/2021

The involvement of APOBEC4 in cancer development has not been extensively studied. However, other members of the APOBEC family, such as APOBEC3 proteins, have been implicated in DNA mutagenesis and cancer progression. Further research is needed to determine if APOBEC4 has any similar roles in cancer development.

Can APOBEC4 be targeted for therapeutic interventions? 11/16/2020

The therapeutic targeting of APOBEC4 has not been explored extensively. However, considering its potential involvement in various cellular processes, modulation of APOBEC4 expression or activity may hold therapeutic potential in the future. Further research is required to evaluate its druggability and therapeutic opportunities.

Can APOBEC4 be used as a biomarker for any diseases? 04/29/2020

Currently, there is no established use of APOBEC4 as a biomarker for any diseases. However, its potential as a diagnostic or prognostic biomarker in certain conditions cannot be ruled out. Ongoing research may provide further insights into its utility as a biomarker.

Are there any diseases or conditions associated with APOBEC4 malfunction or dysregulation? 03/30/2020

Currently, there is limited information on diseases or conditions specifically associated with APOBEC4 malfunction or dysregulation. However, dysregulation of other APOBEC family members has been associated with various diseases, including cancer, autoimmune diseases, and viral infections. It is plausible that dysregulation of APOBEC4 may also contribute to certain diseases, but further investigations are required to establish any direct associations.

Can APOBEC4 be used as a therapeutic target for antiviral therapy? 02/06/2020

The potential of APOBEC4 as a therapeutic target for antiviral therapy has not been extensively explored. However, some members of the APOBEC family, such as APOBEC3 proteins, have shown antiviral activity by restricting the replication of certain viruses. Future research may investigate if APOBEC4 has similar antiviral properties that could be exploited therapeutically.

Are there any known pathological roles of APOBEC4? 01/18/2020

The pathological roles of APOBEC4 are not well-characterized. However, other members of the APOBEC family, such as APOBEC3 proteins, have been implicated in DNA mutagenesis and genomic instability in certain cancers. It is possible that APOBEC4 could have similar pathological effects, but further studies are needed to determine its specific involvement in disease processes.

Can APOBEC4 mutations cause any genetic disorders? 03/27/2018

Currently, there is no known association between APOBEC4 mutations and specific genetic disorders. However, given its potential involvement in various cellular processes, it is possible that mutations in APOBEC4 could contribute to certain genetic disorders. Research in this area is still limited.

Is APOBEC4 involved in viral defense like other APOBEC proteins? 03/15/2018

The role of APOBEC4 in viral defense is not well-characterized. While some studies suggest a potential role in antiviral defense, more research is needed to determine the extent of its involvement in inhibiting viral replication.

What tissues or organs express APOBEC4 protein? 02/02/2018

APOBEC4 is primarily expressed in the reproductive tissues, including the testes and ovaries. However, low levels of expression have also been observed in other tissues such as the brain, lungs, and liver.

How does APOBEC4 contribute to RNA editing? 07/05/2017

The specific contribution of APOBEC4 to RNA editing is not yet clear. RNA editing involves the alteration of RNA sequences, and APOBEC enzymes, including APOBEC4, are known to catalyze cytidine deamination, which can lead to changes in RNA sequences. It is hypothesized that APOBEC4 may participate in this process, but the exact targets and mechanisms of APOBEC4-mediated RNA editing require further investigation.

How is APOBEC4 involved in reproductive processes? 02/14/2017

APOBEC4 is predominantly expressed in the reproductive tissues, such as the testes and ovaries, suggesting a potential role in reproductive processes. However, the exact function of APOBEC4 in reproduction is not yet understood. It is hypothesized to contribute to RNA editing or other regulatory mechanisms associated with gamete development or fertility, but further investigation is needed to fully elucidate its involvement.

Does APOBEC4 have any known interacting proteins? 01/13/2017

The identification of APOBEC4-interacting proteins is an area of ongoing research. However, some studies have suggested possible interactions with other APOBEC family members, RNA-binding proteins, and components of the RNA editing machinery. Further studies will likely unveil additional interacting partners.

Is APOBEC4 involved in DNA editing? 06/28/2016

APOBEC4 is primarily known for its RNA editing capabilities rather than DNA editing. It is considered as an RNA-editing enzyme that deaminates adenosine residues in RNA molecules, leading to the conversion of adenosine to inosine.

Are there any known diseases or conditions associated with APOBEC4 dysregulation? 01/05/2016

At present, there are no known diseases or conditions specifically associated with APOBEC4 dysregulation. However, given its role in the reproductive tissues and potential involvement in other processes, it is plausible that APOBEC4 dysregulation could contribute to certain diseases or conditions. Further research is needed to establish any direct associations.

Customer Reviews (4)

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Reviews
02/19/2021

    APOBEC4 protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

    10/01/2020

      bulk production often leads to economies of scale, making the APOBEC4 protein more cost-effective for research budgets.

      02/02/2019

        Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using APOBEC4 protein.

        02/25/2016

          Manufacturers with the capacity for bulk production can offer APOBEC4 protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.

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