Recombinant Human exosome component 4, His-tagged

• Cat.No.: EXOSC4-332H
• Product Overview: EXOSC4, 1-245aa, Human, His tag, E.coli

Specification

• Description: EXOSC4, also known as fetuin-A, belongs to the fetuin class of plasma binding proteins. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. It is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has been postulated that it participates in the development of the tissues. It forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Recombinant human EXOSC4 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
• Molecular Mass: 28.8 kDa(268aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAGLELL SDQGYRVDGR RAGELRKIQA RMGVFAQADG SAYIEQGNTK ALAVVYGPHE IRGSRARALP DRALVNCQYS SATFSTGERK RRPHGDRKSC EMGLQLRQTF EAAILTQLHP RSQIDIYVQV LQADGGTYAA CVNAATLAVL DAGIPMRDFV CACSAGFVDG TALADLSHVE EAAGGPQLAL ALLPASGQIA LLEMDARLHE DHLERVLEAA AQAARDVHTL LDRVVRQHVR EASILLGD
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: EXOSC4 exosome component 4 [ Homo sapiens ]
• Official Symbol: EXOSC4
• Synonyms: EXOSC4; exosome component 4; exosome complex component RRP41; exosome component Rrp41; FLJ20591; hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6; Ski6p; exosome complex exonuclease RRP41; ribosomal RNA-processing protein 41
• Gene ID: 54512
• mRNA Refseq: NM_019037
• Protein Refseq: NP_061910
• MIM: 606491
• UniProt ID: Q9NPD3
• Chromosome Location: 8q24.3
• Pathway: Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem
• Function: 3-5-exoribonuclease activity; AU-rich element binding; NOT exoribonuclease activity; protein binding