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Recombinant Human adaptor-related protein complex 3, sigma 1 subunit, His-tagged

Cat.No. : AP3S1-364H
Product Overview : AP3S1, 1-193aa, Human, His tag, E.coli
  • Specification
  • Gene Information
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Description : AP-3 complex subunit sigma-1, also known as AP3S1, is a Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Recombinant human AP3S1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Molecular Mass : 23.8 kDa (213aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : AP3S1 adaptor-related protein complex 3, sigma 1 subunit [ Homo sapiens ]
Official Symbol : AP3S1
Synonyms : AP3S1; adaptor-related protein complex 3, sigma 1 subunit; CLAPS3; AP-3 complex subunit sigma-1; sigma3A-adaptin; sigma-3A-adaptin; sigma-adaptin 3a; AP-3 complex sigma-3A subunit; AP-3 complex subunit sigma-3A; adapter-related protein complex 3 sigma-1 subunit; clathrin-associated/assembly/adapter protein, small 3; clathrin-associated/assembly/adaptor protein, small 3 (22kD); Sigma3A;
Gene ID : 1176
mRNA Refseq : NM_001284
Protein Refseq : NP_001275
MIM : 601507
UniProt ID : Q92572
Chromosome Location : 5q22
Pathway : Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem;
Function : protein binding; protein transporter activity; transporter activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What is the research prospect of AP3S1 ? 10/26/2022

Based on the results and therapeutic potential of existing studies, the AP3S1 is promising, but further experiments are needed to confirm its efficacy and safety.

Are there indications to restrict the use of AP3S1 ? 06/21/2022

There are currently no reports of indications restricting the use of AP3S1 , but specific treatment options need to be determined based on the characteristics of the disease.

What is the dose and route of administration of AP3S1 ? 06/20/2022

The specific choice of dose and route of administration depends on the specific disease and treatment regimen, and further research is needed to determine the optimal dose and method of administration.

Which diseases are associated with recombinant AP3S1? 02/10/2022

AP3S1 has been implicated in the repair of error damage, immune regulation and anti-tumor response.

Are there side effects of AP3S1 treatment? 03/08/2021

There have been no definitive reports of side effects, but more clinical trials are needed to assess the potential risks.

How does the efficacy of recombinant AP3S1 compare with other treatments? 12/19/2020

There is a lack of large-scale clinical trial results compared to other treatments, so it is not possible to definitively assess their relative effectiveness.

Which companies or research institutions are currently developing AP3S1 ? 04/04/2020

A number of companies and research institutions are currently conducting research related to AP3S1 s, including pharmaceutical companies, university laboratories and scientific research institutions.

What are the applications of AP3S1 in clinical treatment? 12/11/2019

AP3S1 has potential applications in immunotherapy, DNA repair therapy and tumor targeting therapy.

How to evaluate the therapeutic effect of AP3S1 ? 07/17/2019

Clinical trials, cell culture experiments, animal models, and molecular biological methods can be used to evaluate the therapeutic effect of AP3S1 .

How is the research progress of AP3S1 ? 02/13/2019

Current studies have shown that the AP3S1 has a potentially important role in the treatment of many diseases, and further studies are currently being conducted to explore its mechanisms and applications.

Customer Reviews (4)

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Reviews
01/24/2022

    Reproducibility of AP3S1 is very good, which greatly reduces experimental error and allows me to evaluate experimental results more accurately.

    11/12/2021

      With short half-life and high clearance characteristics, it has higher potential in drug development and is expected to become a new generation of therapeutic drugs.

      05/01/2021

        Stability of AP3S1 is very good, and a variety of experimental operations can be performed without worrying about changes and effects on its performance.

        11/27/2019

          Resolution in Western blot is high, which can distinguish similar protein molecular weights.

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