Recombinant Human adaptor-related protein complex 3, sigma 1 subunit, His-tagged
Cat.No. : | AP3S1-364H |
Product Overview : | AP3S1, 1-193aa, Human, His tag, E.coli |
- Specification
- Gene Information
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Description : | AP-3 complex subunit sigma-1, also known as AP3S1, is a Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Recombinant human AP3S1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Source : | E.coli |
Species : | Human |
Tag : | His-tag |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
Molecular Mass : | 23.8 kDa (213aa) confirmed by MALDI-TOF |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | AP3S1 adaptor-related protein complex 3, sigma 1 subunit [ Homo sapiens ] |
Official Symbol : | AP3S1 |
Synonyms : | AP3S1; adaptor-related protein complex 3, sigma 1 subunit; CLAPS3; AP-3 complex subunit sigma-1; sigma3A-adaptin; sigma-3A-adaptin; sigma-adaptin 3a; AP-3 complex sigma-3A subunit; AP-3 complex subunit sigma-3A; adapter-related protein complex 3 sigma-1 subunit; clathrin-associated/assembly/adapter protein, small 3; clathrin-associated/assembly/adaptor protein, small 3 (22kD); Sigma3A; |
Gene ID : | 1176 |
mRNA Refseq : | NM_001284 |
Protein Refseq : | NP_001275 |
MIM : | 601507 |
UniProt ID : | Q92572 |
Chromosome Location : | 5q22 |
Pathway : | Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem; |
Function : | protein binding; protein transporter activity; transporter activity; |
Products Types
◆ Recombinant Protein | ||
Ap3s1-192R | Recombinant Rat Ap3s1 Protein, His-tagged | +Inquiry |
AP3S1-191H | Recombinant Human AP3S1 Protein, His-tagged | +Inquiry |
AP3S1-1723C | Recombinant Chicken AP3S1 | +Inquiry |
AP3S1-1494Z | Recombinant Zebrafish AP3S1 | +Inquiry |
AP3S1-659H | Recombinant Human AP3S1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
AP3S1-8808HCL | Recombinant Human AP3S1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionBased on the results and therapeutic potential of existing studies, the AP3S1 is promising, but further experiments are needed to confirm its efficacy and safety.
There are currently no reports of indications restricting the use of AP3S1 , but specific treatment options need to be determined based on the characteristics of the disease.
The specific choice of dose and route of administration depends on the specific disease and treatment regimen, and further research is needed to determine the optimal dose and method of administration.
AP3S1 has been implicated in the repair of error damage, immune regulation and anti-tumor response.
There have been no definitive reports of side effects, but more clinical trials are needed to assess the potential risks.
There is a lack of large-scale clinical trial results compared to other treatments, so it is not possible to definitively assess their relative effectiveness.
A number of companies and research institutions are currently conducting research related to AP3S1 s, including pharmaceutical companies, university laboratories and scientific research institutions.
AP3S1 has potential applications in immunotherapy, DNA repair therapy and tumor targeting therapy.
Clinical trials, cell culture experiments, animal models, and molecular biological methods can be used to evaluate the therapeutic effect of AP3S1 .
Current studies have shown that the AP3S1 has a potentially important role in the treatment of many diseases, and further studies are currently being conducted to explore its mechanisms and applications.
Customer Reviews (4)
Write a reviewReproducibility of AP3S1 is very good, which greatly reduces experimental error and allows me to evaluate experimental results more accurately.
With short half-life and high clearance characteristics, it has higher potential in drug development and is expected to become a new generation of therapeutic drugs.
Stability of AP3S1 is very good, and a variety of experimental operations can be performed without worrying about changes and effects on its performance.
Resolution in Western blot is high, which can distinguish similar protein molecular weights.
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