"SNURF" Related Products

Recombinant Human SNRPN upstream reading frame, His-tagged

Cat.No.: SNURF-431H
Product Overview: SNURF, 1-71aa, Human, His tag, E.coli
Description: SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5" untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5" UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known. Recombinant human SNURF protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source: E.coli
Species: Human
Tag: His-tag
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 40% glycerol, 1mM DTT.
Molecular Mass: 10.8 kDa (94aa) confirmed by MALDI-TOF
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMERARDR LHLRRTTEQH VPEVEVQVKR RRTASLSNQE CQLYPRRSQQ QQVPVVDFQA ELRQAFLAET PRGG
Purity: >90% by SDS - PAGE
Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration: 0.25 mg/ml (determined by Bradford assay)
Gene Name: SNURF?SNRPN upstream reading frame [?Homo sapiens?(human) ]
Official Symbol: SNURF
Synonyms: SNURF; SNRPN upstream reading frame; SNRPN upstream reading frame protein
Gene ID: 8926
mRNA Refseq: NM_005678
Protein Refseq: NP_005669
UniProt ID: Q9Y675
Chromosome Location: 15q12
Pathway: Coregulation of Androgen receptor activity; Gastric cancer network 2; mRNA processing
Function: molecular_function

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