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Recombinant Human secreted frizzled-related protein 2, His-tagged

Cat.No. : SFRP2-509H
Product Overview : SFRP2, 20-295aa Human, His tag, E.coli
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  • Gene Information
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Description : SFRP2, as known as secreted frizzled-related protein 2, is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. This protein acts as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. Recombinant human SFRP2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
Molecular Mass : 33.8 kDa(297aa)
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSARGLFLF GQPDFSYKRS NCKPIPVNLQ LCHGIEYQNM RLPNLLGHET MKEVLEQAGA WIPLVMKQCH PDTKKFLCSL FAPVCLDDLD ETIQPCHSLC VQVKDRCAPV MSAFGFPWPD MLECDRFPQD NDLCIPLASS DHLLPATEEA PKVCEACKNK NDDDNDIMET LCKNDFALKI KVKEITYINR DTKIILETKS KTIYKLNGVS ERDLKKSVLW LKDSLQCTCE EMNDINAPYL VMGQKQGGEL VITSVKRWQK GQREFKRISR SIRKLQC
Purity : >85% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1mg/ml (determined by Bradford assay)
Gene Name : SFRP2 secreted frizzled-related protein 2 [ Homo sapiens ]
Official Symbol : SFRP2
Synonyms : SFRP2; secreted frizzled-related protein 2; FRP 2; SARP1; SDF 5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1; FRP-2; SDF-5;
Gene ID : 6423
mRNA Refseq : NM_003013
Protein Refseq : NP_003004
MIM : 604157
UniProt ID : Q96HF1
Chromosome Location : 4q31.3
Pathway : Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem;
Function : PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; endopeptidase activator activity; fibronectin binding; integrin binding; metalloenzyme activator activity; receptor agonist activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does SFRP2 expression influence stem cell differentiation and regeneration in various tissues? 01/11/2022

SFRP2 expression plays a significant role in stem cell differentiation, contributing to tissue regeneration and repair processes.

What role does SFRP2 play in the development and progression of cardiovascular diseases, especially atherosclerosis? 08/22/2021

In cardiovascular diseases, SFRP2 plays a role in processes like atherosclerosis, impacting vascular health and disease progression.

What is the impact of SFRP2 on angiogenesis in the context of tumor growth and metastasis? 02/20/2021

SFRP2 influences angiogenesis in tumors, affecting tumor growth and the potential for metastasis.

How does SFRP2 interact with Wnt signaling pathways in cancer development, particularly in colorectal and breast cancers? 11/06/2020

SFRP2 modulates Wnt signaling in cancers, with specific roles in colorectal and breast cancer development, impacting cell proliferation and migration.

How does SFRP2 modulate bone formation and resorption in osteoporosis and other bone diseases? 05/24/2020

SFRP2 is involved in bone metabolism, affecting bone formation and resorption in diseases like osteoporosis.

What are the mechanisms by which SFRP2 contributes to fibrosis in organ systems like the heart and liver? 03/02/2020

SFRP2 contributes to fibrosis in organs like the heart and liver, influencing tissue remodeling and function.

How does the alteration of SFRP2 expression affect adipogenesis and metabolic processes in obesity and diabetes? 11/17/2018

Alterations in SFRP2 expression affect adipogenesis and metabolic functions, linking it to obesity and diabetes pathologies.

Customer Reviews (3)

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Reviews
11/13/2021

    Fast and affordable protein sequencing; great for identifying unknown proteins.

    04/28/2019

      Robust protein-protein interaction assays; pivotal for our experiments.

      02/20/2018

        High-quality protein crystallization; crucial for structural biology studies.

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