Recombinant Human secreted frizzled-related protein 2, His-tagged

• Cat.No.: SFRP2-509H
• Product Overview: SFRP2, 20-295aa Human, His tag, E.coli

Specification

• Description: SFRP2, as known as secreted frizzled-related protein 2, is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. This protein acts as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. Recombinant human SFRP2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Source: E.coli
• Species: Human
• Tag: His-tag
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.4M Urea
• Molecular Mass: 33.8 kDa(297aa)
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSARGLFLF GQPDFSYKRS NCKPIPVNLQ LCHGIEYQNM RLPNLLGHET MKEVLEQAGA WIPLVMKQCH PDTKKFLCSL FAPVCLDDLD ETIQPCHSLC VQVKDRCAPV MSAFGFPWPD MLECDRFPQD NDLCIPLASS DHLLPATEEA PKVCEACKNK NDDDNDIMET LCKNDFALKI KVKEITYINR DTKIILETKS KTIYKLNGVS ERDLKKSVLW LKDSLQCTCE EMNDINAPYL VMGQKQGGEL VITSVKRWQK GQREFKRISR SIRKLQC
• Purity: >85% by SDS - PAGE
• Storage: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
• Concentration: 1mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: SFRP2 secreted frizzled-related protein 2 [ Homo sapiens ]
• Official Symbol: SFRP2
• Synonyms: SFRP2; secreted frizzled-related protein 2; FRP 2; SARP1; SDF 5; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1; FRP-2; SDF-5
• Gene ID: 6423
• mRNA Refseq: NM_003013
• Protein Refseq: NP_003004
• MIM: 604157
• UniProt ID: Q96HF1
• Chromosome Location: 4q31.3
• Pathway: Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem
• Function: PDZ domain binding; Wnt-activated receptor activity; Wnt-protein binding; endopeptidase activator activity; fibronectin binding; integrin binding; metalloenzyme activator activity; receptor agonist activity