Recombinant Human hydroxysteroid (17-beta) dehydrogenase 1, His-tagged HSD17B1-586H

Recombinant Human hydroxysteroid (17-beta) dehydrogenase 1, His-tagged

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Recombinant Human hydroxysteroid (17-beta) dehydrogenase 1, His-tagged

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Cat.No. : HSD17B1-586H
Product Overview : HSD17B1, 1-328aa, Human, His tag, E.coli
Description : Estradiol 17-beta-dehydrogenase 1, also known as HSD17B1, belongs to the short-chain dehydrogenases/reductases (SDR) family. This protein favors the reduction of estrogens and androgens. Recombinant human HSD17B1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Molecular Mass : 37.5kDa (352aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMARTVV LITGCSSGIG LHLAVRLASD PSQSFKVYAT LRDLKTQGRL WEAARALACP PGSLETLQLD VRDSKSVAAA RERVTEGRVD VLVCNAGLGL LGPLEALGED AVASVLDVNV VGTVRMLQAF LPDMKRRGSG RVLVTGSVGG LMGLPFNDVY CASKFALEGL CESLAVLLLP FGVHLSLIEC GPVHTAFMEK VLGSPEEVLD RTDIHTFHRF YQYLAHSKQV FREAAQNPEE VAEVFLTALR APKPTLRYFT TERFLPLLRM RLDDPSGSNY VTAMHREVFG DVPAKAEAGA EAGGGAGPGA EDEAGRGAVG DPELGDPPAA PQ
Purity : >90 % by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 [ Homo sapiens ]
Official Symbol : HSD17B1
Synonyms : HSD17B1; hydroxysteroid (17-beta) dehydrogenase 1; EDH17B2, EDHB17; estradiol 17-beta-dehydrogenase 1; Estradiol 17 beta dehydrogenase 1; HSD17; MGC138140; SDR28C1; short chain dehydrogenase/reductase family 28CE; member 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1; EDHB17; EDH17B2;
Gene ID : 3292
mRNA Refseq : NM_000413
Protein Refseq : NP_000404
MIM : 109684
UniProt ID : P14061
Chromosome Location : 17q11-q21
Pathway : Estrogen biosynthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Metabolism of steroid hormones and vitamins A and D, organism-specific biosystem; Steroid Biosynthesis, organism-specific biosystem; Steroid hormone biosynthesis, organism-specific biosystem;
Function : catalytic activity; estradiol 17-beta-dehydrogenase activity; nucleotide binding; oxidoreductase activity;

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