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Recombinant Mouse Fcgr2b, His & AVI Tagged, Biotinylated

Cat.No.: Fcgr2b-2968M
Product Overview: A DNA sequence encoding the extracellular domain (Met 1-Arg 217) of mouse FGGR2B (NP_001070657.1) as fused with a c-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Description: FcRII (CD32) is a low affinity receptor for IgG that binds only IgG immune complexes and is expressed on a diverse range of cells such as monocytes, macrophages, neutrophils, eosinophils, platelets, and B cells. There are three main classes of human leucocyte IgG Fc receptor (FcR) : FcRI (CD64), FcRII (CD32), and FcR (CD16) which are distinguished on the basis of molecular weights, cellular distribution, affinity/specificity for ligand and by reactivity with monoclonal antibodies. Many important functions have been attributed to these receptors and they are regarded as providing an essential link between cellular and humoral immune systems. The most ubiquitous of these receptors is FcRII. The extracellular region of FcRII comprises two C2-type Ig-like disulfide-bonded domains which is structurally conserved in all of the Ig superfamily leukocyte FcRs (and represents an Ig-interactive motif. FcRII is involved in a number of immune responses including antibody-dependent cell-mediated cytotoxicity, clearance of immune complexes, release of inflammatory mediators, and regulation of antibody production.
Source: Human Cells
Species: Mouse
Tag: His & AVI Tag
Form: Lyophilized from sterile PBS , pH 7.4
Molecular Mass: The secreted recombinant mouse FGGR2B consists of 212 amino acids and has a predicted molecular mass of 23.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm FGGR2B is approximately 38-43 kDa due to glycosylation.
Protein length: Met1-Arg217
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >97 % as determined by SDS-PAGE
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: Reconstitute with water to desired concentration.
Gene Name: Fcgr2b Fc receptor, IgG, low affinity IIb [ Mus musculus ]
Official Symbol: Fcgr2b
Synonyms: FCGR2B; Fc receptor, IgG, low affinity IIb; low affinity immunoglobulin gamma Fc region receptor II-b; fcRII; FcgammaRIIB; Fc-gamma-RII; fc-gamma RII; Fc gamma RIIB; fc-gamma-RIIB; fc gamma receptor IIB; lymphocyte antigen 17; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; FcgRII; Fcgr2a; Ly-m20; AI528646; Fc[g]RII; F630109E10Rik;
Gene ID: 14130
mRNA Refseq: NM_001077189
Protein Refseq: NP_001070657
Pathway: Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Immune System, organism-specific biosystem;
Function: IgG binding; protein binding; receptor activity; receptor signaling protein activity;

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