"ERBB2" Related Products

Recombinant Cynomolgus ERBB2, His-tagged

Cat.No.: ERBB2-206C
Product Overview: A DNA sequence encoding the cynomolgus ERBB2 (Met1-Thr652) [Rhesus ERBB2 (XP_001090430.1,Asp121Asn,Leu122Pro); similar to Macaca fascicularis ERBB2 (EHH58073.1)] was expressed with a polyhistidine tag at the C-terminus.
Description: Receptor tyrosine-protein kinase erbB-2, also known as epidermal growth factor receptor-related protein, proto-oncogene Neu, proto-oncogene cErbB-2, CD340 and ErbB2, is a single-pass type I? membrane protein, cytoplasm protein and nucleus protein which belongs to the?protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. The ErbB protein family, also known as epidermal growth factor receptor (EGFR) family, is a family of four structurally related receptor tyrosine kinases ( ErbB1 / EGFR , ErbB2 / HER2 , ErbB3 / HER3 , ErbB4 / HER4 ). The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: Erythroblastic Leukemia Viral Oncogene. Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer"s Disease.? Mouse ErbB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for rat ErbB2. It binds to the 5"-TCAAATTC-3" sequence in the MTCO2 promoter and activates its transcription. ErbB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. ErbB2 cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. This receptor forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays an key role in development, cell proliferationand differentiation.
Source: Human Cells
Species: Cynomolgus
Tag: His
Form: Lyophilized from sterile PBS, pH7.4.
Molecular Mass: The recombinant cynomolgus ERBB2 comprises 641 amino acids and has a calculated molecular mass of 70.8 KDa. The apparent molecular mass of it is approximately 80-105 KDa in SDS-PAGE under reducing conditions.
Protein length: Met1-Thr652
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >90 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name: ERBB2?v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 [Macaca fascicularis?(crab-eating macaque) ]
Official Symbol: ERBB2
Synonyms: ERBB2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Gene ID: 102146608
mRNA Refseq: XM_005584035
Protein Refseq: XP_005584092
Chromosome Location: 16
Pathway: Adherens junction; Bladder cancer; ErbB signaling pathway

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