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Recombinant Human CD48, Fc-tagged

Cat.No.: CD48-252H
Product Overview: A DNA sequence encoding the human CD48 (NP_001769.2) (Met1-Ser220) was expressed with the Fc region of human IgG1 at the C-terminus.
Description: CD48, also known as SLAMF2, BCM-1 and BLAST-1, is a 65 kDa GPIlinked protein belonging to the CD2 subfamily of immunoglobulinsuperfamily molecules. In rodents, CD48 is the ligand for CD2 whereas in humans, CD58 is the ligand for CD2. Human CD48 cDNA encodes a 243 aa precursor that includes a 26 aa signal sequence, a 194 aa mature protein that contains one Ig-like V-type domain and one Ig-like C2-type domain, and a 23 aa C-terminal propeptide. It has a high degree of sequence homology to CD58 (LFA-3), and human CD48 shares approximately 50% aa sequence identity with mouse and rat CD48. CD48 is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.
Source: Human Cells
Species: Human
Tag: Fc
Form: Lyophilized from sterile PBS, pH7.4.
Molecular Mass: The recombinant human CD48/Fc comprises 432 amino acids and has a predicted molecular mass of 49.1 kDa. The apparent molecular mass of the protein is approximately 64.5 kDa in SDS-PAGE under reducing conditions.
Protein length: Met1-Ser220
Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
Purity: >90 % as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name: CD48 CD48 molecule [ Homo sapiens ]
Official Symbol: CD48
Synonyms: CD48; CD48 molecule; BCM1, CD48 antigen (B cell membrane protein) , CD48 molecule; CD48 antigen; BLAST; hCD48; mCD48; SLAMF2; TCT.1; BCM1 surface antigen; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); BCM1; BLAST1; MEM-102;
Gene ID: 962
mRNA Refseq: NM_001256030
Protein Refseq: NP_001242959
MIM: 109530
UniProt ID: P09326
Chromosome Location: 1q21.3-q22
Pathway: Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem;
Function: antigen binding; eukaryotic cell surface binding; protein binding; receptor activity;

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