Recombinant Human ABHD16A, His-tagged
Cat.No. : | ABHD16A-3039H |
Product Overview : | Abhydrolase domain-containing protein 16A (ABHD16A) |
- Specification
- Gene Information
- Related Products
Description : | A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] |
Source : | E. Coli or Yeast |
Species : | Human |
Tag : | His |
Form : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Protein length : | 558 |
Purity : | >90% |
Notes : | Small volumes of ABHD16A recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Store at -20 degree C. For extended storage, store at -20 or -80 degree C. |
Storage Buffer : | PBS pH 7.4, 50% glycerol |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | ABHD16A abhydrolase domain containing 16A [ Homo sapiens ] |
Official Symbol : | ABHD16A |
Synonyms : | abhydrolase domain containing 16A; PP199; BAT5; abhydrolase domain-containing protein 16A; NG26; EC 3.-.-.-; D6S82E; G5; HLA-B associated transcript 5; HLA-B-associated transcript 5; Protein G5; |
Gene ID : | 7920 |
mRNA Refseq : | NM_021160.2 |
Protein Refseq : | NP_066983.1 |
MIM : | 142620 |
UniProt ID : | O95870 |
Chromosome Location : | 6p21.3 |
Function : | hydrolase activity |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionUsing STED microscopy, we can found that mammalian ABHD12 is enriched at the ER membrane30, then checked for the co-localization of ABHD16A with ABHD12. Indeed, we found in Neuro-2a cells, that ABHD16A co-localizes with ABHD12, further confirming that ABHD16A is enriched at the ER membrane.
A complicated hereditary spastic paraplegia (HSP) caused by ABHD16A loss of function pathogenic variants and the subsequent altered phosphatidylserine (PS) metabolism.
The protein deglycosylation studies and the detergent-independent sensitivity of ABHD16A to proteolytic degradation, have suggested this point.
Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B
They are DTX2, RNF5, AGPAT3, TMEM147, and FAM134C.
ABHD16A is a 21-exon gene which encodes for the α/β hydrolase domain-containing 16A (ABHD16A) enzyme, which is the main brain phosphatidylserine (PS) hydrolase.
ABHD16A and ABHD12, are the main enzymes responsible for the brain LPS metabolism, as ABHD16A generates LPS while ABHD12 catabolizes them into fatty acid and phosphoserine.
ABHD16A PS lipase deficiency results in intellectual disability, progressive spasticity, abnormal corpus callosum, and white matter anomalies, most likely through the dysregulation of lipid species including lyso-PS.
We found relative to the tubulin protein loading control, that ABHD16A was maximally enriched in the cerebellum, and the olfactory bulb, while ABHD12 is ubiquitously expressed at near equal levels in all the aforementioned brain regions.
ABHD16A has a heterogeneous expression in the murine brain and is enriched in the cerebellum, particularly in the granular layer and the olfactory bulb.
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