Recombinant Human ADCY9, His-tagged, T7 tagged
Cat.No. : | ADCY9-3168H |
Product Overview : | Adenylate Cyclase 9 (ADCY9) |
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Description : | Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. |
Source : | E. Coli |
Species : | Human |
Tag : | His,T7 |
Form : | Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl. |
Molecular Mass : | 32.6kDa |
Protein length : | 1353 |
Endotoxin : | <1.0eu per 1ug (determined by the lal</1.0eu |
Purity : | >95% |
Applications : | SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP) |
Notes : | Small volumes of ADCY9 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Warning : | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Gene Name : | ADCY9 adenylate cyclase 9 [ Homo sapiens ] |
Official Symbol : | ADCY9 |
Synonyms : | ADCY9; adenylate cyclase 9; adenylate cyclase type 9; AC9; adenylyl cyclase 9; ATP pyrophosphate-lyase 9; adenylate cyclase type IX; type IX ATP pyrophosphate-lyase; FLJ12046; |
Gene ID : | 115 |
mRNA Refseq : | NM_001116 |
Protein Refseq : | NP_001107 |
MIM : | 603302 |
UniProt ID : | O60503 |
Chromosome Location : | 16p13.3 |
Pathway : | Activation of GABAB receptors, organism-specific biosystem; Adenylate cyclase activating pathway, organism-specific biosystem; Adenylate cyclase inhibitory pathway, organism-specific biosystem; Aquaporin-mediated transport, organism-specific biosystem; Bi |
Function : | ATP binding; GTPase activity; adenylate cyclase activity; metal ion binding; nucleotide binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionTargeting Adcy9 protein may have therapeutic applications in various diseases and conditions, including neurological disorders (such as epilepsy and Parkinson's disease), cardiovascular diseases, obesity and diabetes, and immune disorders (such as autoimmune diseases and cancer).
As Adcy9 is involved in various signaling pathways and physiological responses, potential biomarkers for monitoring the efficacy of Adcy9-targeted therapies may depend on the disease or condition being treated. For example, in neurological disorders, biomarkers such as seizure frequency, dopamine levels, and neuroimaging measures may be used. In cardiovascular diseases, biomarkers such as blood pressure and heart rate may be monitored. In immune disorders, biomarkers such as cytokine levels and immune cell function may be measured.
One challenge in developing Adcy9-targeted therapies is identifying drugs that specifically modulate Adcy9 activity without affecting other cAMP-producing enzymes. Another challenge is understanding the complex interactions between cAMP signaling pathways and other signaling pathways in the brain and throughout the body. These factors highlight the need for further research to develop effective and safe therapies targeting Adcy9.
Researchers use a variety of techniques to study Adcy9 activity and regulation, including molecular cloning, protein expression and purification, enzymatic assays, microscopy, and genetic manipulation in animal models. These techniques allow for a deeper understanding of Adcy9 function and potential therapeutic applications.
As of 2021, there are no drugs targeting Adcy9 that have reached clinical trials. However, several small molecule inhibitors of Adcy9 are being developed by pharmaceutical companies and tested in preclinical studies.
While Adcy9 has been implicated in various neurological disorders, it may not be specific enough as a biomarker for these disorders. Further research is needed to identify more specific biomarkers for diagnosis and monitoring of neurological disorders.
Yes, Adcy9 has been identified as a potential therapeutic target for various neurological disorders such as depression, anxiety, and addiction. There is ongoing research to develop drugs that modulate Adcy9 activity, either by inhibiting or enhancing its function, as a potential treatment strategy for these disorders.
Yes, genetic mutations in Adcy9 have been associated with various neurological disorders, such as bipolar disorder, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). These mutations can affect the function and regulation of Adcy9, leading to changes in cAMP levels and neuronal signaling that contribute to the development of these disorders.
One challenge in developing Adcy9-targeted therapies is that Adcy9 is not the only adenylate cyclase isoform expressed in cells and tissues, and its physiological roles and functions may overlap with those of other adenylate cyclases. This may lead to off-target effects and toxicity of Adcy9-specific drugs. Additionally, the complex regulation and interactions of Adcy9 with other signaling pathways may complicate the design and optimization of Adcy9-targeted therapeutics.
In addition to its potential role in neurological disorders, Adcy9 research may have applications in other areas such as obesity and diabetes. Studies have shown that cAMP signaling can affect glucose and lipid metabolism, and Adcy9 has been linked to insulin resistance in obesity and type 2 diabetes. Therefore, targeting Adcy9 activity may have potential therapeutic benefits for these conditions.
Various approaches are being explored for targeting Adcy9 protein in drug development, including small molecule inhibitors, RNA interference (RNAi), and gene therapy. Small molecule inhibitors that target Adcy9 activity or expression are being developed and tested in preclinical studies. RNAi technology is being used to silence Adcy9 expression in cells and animal models, and gene therapy approaches are being explored to deliver Adcy9-targeted therapeutics to specific tissues.
Adcy9 activity is regulated by a variety of factors including G protein-coupled receptor signaling, calcium signaling, and phosphorylation by protein kinase A. These processes can affect Adcy9 localization and stability, as well as its ability to produce cAMP.
Measuring Adcy9 protein levels alone may not be sufficient for diagnosis of diseases. However, measuring Adcy9 activity or levels in conjunction with other diagnostic tests may provide additional information for disease diagnosis, prognosis, and treatment.
Adcy9 is primarily expressed in the brain, but it has also been found in other tissues including the heart, lungs, and adrenal glands. The expression levels of Adcy9 in these tissues are relatively low compared to the brain, suggesting a more specific role in neuronal signaling.
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