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Recombinant Rat Arl2, His-tagged

Cat.No. : Arl2-3212R
Product Overview : ADP-ribosylation factor-like protein 2 (Arl2)
  • Specification
  • Gene Information
  • Related Products
Description : plays a role in the secretory pathway; mediates Ca2(+)-dependent release of acetylcholine .
Source : E. Coli or Yeast
Species : Rat
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 184
Purity : >90%
Notes : Small volumes of Arl2 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Arl2 ADP-ribosylation factor-like 2 [ Rattus norvegicus ]
Official Symbol : Arl2
Synonyms : ARL2; ADP-ribosylation factor-like 2; ADP-ribosylation factor-like protein 2; ADP-ribosylation-like 2;
Gene ID : 65142
mRNA Refseq : NM_031711
Protein Refseq : NP_113899
Function : GDP binding; GDP binding; GTP binding; GTP binding; GTPase activity; GTPase activity; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (15)

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Are there any reported genetic variations or mutations in the ARL2 gene? 08/10/2022

Yes, there have been reports of genetic variations and mutations in the ARL2 gene. Some single nucleotide polymorphisms (SNPs) have been identified, although their functional consequences are not yet fully understood.

Where is ARL2 protein predominantly localized within the cell? 06/10/2022

ARL2 protein is primarily localized in the cytoplasm, but it can also be found associated with the plasma membrane and mitochondria.

Can ARL2 protein affect cellular processes independent of its nucleotide binding state? 05/10/2021

Yes, apart from its activity as a GTPase, ARL2 protein can have nucleotide-independent functions as well. It has been reported to interact with various proteins and participate in protein-protein interactions that are not solely dependent on its nucleotide-bound state.

Is ARL2 protein conserved across different species? 05/02/2021

Yes, ARL2 protein is highly conserved across different species, indicating its importance in cellular functions. The amino acid sequence of ARL2 shows a high degree of similarity, even in organisms ranging from yeast to humans.

Are there any known interacting partners of ARL2 protein? 09/28/2020

Yes, ARL2 protein interacts with several proteins to fulfill its diverse functions. Some known interacting partners include UNC119, ARL2BP, ARL3, ARF GAPs (ADP-ribosylation factor GTPase-activating proteins), and molecular motors such as dynein and kinesin.

Can ARL2 be targeted for therapeutic interventions? 08/19/2020

In theory, ARL2 or its associated pathways could be potential targets for therapeutic interventions. However, further research is needed to fully understand the implications of modulating ARL2 function and its downstream effects before developing targeted therapies.

Are there any known interacting partners of ARL2 protein? 01/22/2020

Yes, ARL2 has been found to interact with multiple proteins. Some of its known binding partners include N-myristoyltransferase (NMT), ARL2-interacting protein (ARL2IP), and tubulin, among others.

Is ARL2 protein involved in any cellular processes related to mitochondrial function? 05/07/2019

Yes, ARL2 protein plays a role in mitochondrial functions such as mitochondrial dynamics, fusion, and fission. It has been shown to interact with proteins involved in these processes, suggesting its involvement in maintaining mitochondrial homeostasis.

Are there any diseases associated with mutations in the ARL2 gene? 01/05/2019

Currently, there are no known diseases specifically associated with mutations in the ARL2 gene. However, as more research is conducted, it's possible that specific mutations or dysregulation of ARL2 could be linked to certain diseases or pathological conditions.

Can ARL2 protein regulate cell proliferation or apoptosis? 11/28/2017

There is some evidence suggesting that ARL2 protein might have a role in regulating cell proliferation and apoptosis. However, the exact mechanisms and signaling pathways involved are not fully understood and require further investigation.

Does ARL2 play a role in neurodegenerative diseases? 05/20/2017

ARL2 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. It has been shown to interact with proteins involved in these diseases, suggesting its potential involvement in their pathogenesis. However, more research is needed to fully understand its role in these conditions.

Does ARL2 have any regulatory roles in cancer? 05/19/2017

There is evidence suggesting that ARL2 may have regulatory roles in cancer. It has been found to be differentially expressed in certain cancer types, and its overexpression has been associated with tumor progression and metastasis. However, more research is needed to fully understand its exact role in cancer.

How is ARL2 protein involved in protein trafficking? 06/27/2016

ARL2 protein participates in protein trafficking by regulating the recruitment and functioning of molecular motors, such as dynein and kinesin, on the microtubule tracks. It determines the direction and speed of transport of cargo-containing vesicles within the cell.

Is ARL2 protein localized to specific cellular compartments? 06/20/2016

Yes, ARL2 protein is known to localize to various cellular compartments, including the cytoplasm, nucleus, and mitochondria. Its localization can vary depending on the specific cellular context and the proteins it interacts with.

Is ARL2 protein involved in signal transduction pathways? 06/17/2016

While ARL2 protein itself is not directly involved in traditional signal transduction pathways, it can interact with and modulate the functions of proteins that participate in various signaling cascades. These interactions can indirectly influence signal transduction processes in the cell.

Customer Reviews (10)

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Reviews
03/09/2023

    Its high sensitivity enables the identification of low abundance targets, making it highly valuable in immunological research.

    12/06/2022

      the ARL2 protein has proven to be an invaluable asset in protein electron microscopy structure analysis.

      06/11/2022

        the ARL2 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.

        07/10/2021

          Researchers who have utilized ARL2 protein praise its exceptional performance and reliability in their experiments.

          07/13/2020

            Its versatility in various biological applications, coupled with its compatibility with diverse techniques, makes it a preferred reagent for researchers in the field.

            12/08/2019

              it has demonstrated remarkable effectiveness in ELISA experiments, showcasing its reliability and accuracy in detecting and quantifying specific targets.

              12/12/2017

                Its stability and compatibility with electron microscopy techniques make it an ideal candidate for studying protein structures at high resolution.

                12/16/2016

                  Scientists who have employed ARL2 protein in their experiments have praised its outstanding performance and reliability.

                  11/01/2016

                    The reliable performance of the ARL2 protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

                    05/25/2016

                      The ARL2 protein comes highly recommended for its exceptional performance in various research applications.

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