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Recombinant Human a1ACT, His-tagged, GST-tagged

Cat.No. : a1ACT-3300H
Product Overview : Alpha-1-Antichymotrypsin (a1ACT)
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein"s sequence have been implicated in Alzheimer"s disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Source : E. Coli
Species : Human
Tag : His,GST
Form : Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Molecular Mass : 45.1kDa
Protein length : 423
Endotoxin : <1.0eu per 1ug (determined by the lal</1.0eu
Purity : >95%
Applications : SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
Notes : Small volumes of a1ACT recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 [ Homo sapiens ]
Official Symbol : SERPINA3
Synonyms : ACT; AACT; GIG24; GIG25; alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
Gene ID : 12
mRNA Refseq : NM_001085
Protein Refseq : NP_001076
MIM : 107280
UniProt ID : P01011
Chromosome Location : 14q32.1
Pathway : Selenium Pathway, organism-specific biosystem
Function : DNA binding; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the physiological roles of Serpina3n? 10/13/2022

Serpina3n plays significant roles in various physiological processes, including modulation of the complement cascade, apoptosis, wound healing, and potential implications in Alzheimer's disease.

What is the significance of Serpina3n in pathologies? 03/31/2022

Recent studies have reported significant roles of Serpina3n during various pathologies, particularly in central nervous system (CNS) insults, making it a potential therapeutic target.

What is the aim of literature drawing together Serpina3n applications? 03/26/2021

The aim is to compile literature shedding light on the potential therapeutic applications of Serpina3n/SERPINA3 in various diseases. Additionally, a brief comparison between murine Serpina3n and its human ortholog SERPINA3 (α1-antichymotrypsin) is provided to account for their biological roles and significance.

Are the full range of Serpina3n applications known? 07/21/2020

The full range of potential applications of Serpina3n is yet to be fully revealed, but its reported implications, especially in CNS insults, suggest potential therapeutic applications.

What is Serpina3n? 05/06/2020

Serpina3n is a secretory serine protease inhibitor belonging to clade "a" with unique structural and physiological characteristics. |

How does Serpina3n inhibit proteases? 05/12/2017

Serpina3n inhibits a wide range of proteases, contributing to its diverse physiological roles.

To which clade does Serpina3n belong? 03/07/2016

Serpina3n belongs to clade "a" of serine protease inhibitors. |

Customer Reviews (3)

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Reviews
03/14/2022

    The product's impact extended to data analysis, with intuitive tools for interpreting experimental results.

    06/14/2020

      The longevity of the product's effects allowed us to study cellular responses over extended timeframes.

      10/31/2017

        We found that the product's support for data analysis and visualization significantly expedited our research.

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