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Recombinant Human aHSP, His-tagged, S tagged

Cat.No. : aHSP-3367H
Product Overview : Alpha-Hemoglobin Stabilizing Protein (aHSP)
  • Specification
  • Gene Information
  • Related Products
Description : About the Marker: Effective Size Range: 10kDa to 70kDa.Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.Ready-to-use: No need to heat, dilute or add reducing agents before use.
Source : E. Coli
Species : Human
Tag : His,S
Form : Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Molecular Mass : 17.6kDa
Protein length : 102
Endotoxin : <1.0eu per 1ug (determined by the lal</1.0eu
Purity : >95%
Applications : SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
Notes : Small volumes of aHSP recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : AHSP alpha hemoglobin stabilizing protein [ Homo sapiens ]
Official Symbol : aHSP
Synonyms : AHSP; alpha hemoglobin stabilizing protein; ERAF, erythroid associated factor; alpha-hemoglobin-stabilizing protein; alpha hemoglobin stabilising protein; EDRF; erythroid associated factor; erythroid-associated factor; erythroid differentiation-related factor; erythroid differentiation associated factor; ERAF;
Gene ID : 51327
mRNA Refseq : NM_016633
Protein Refseq : NP_057717
MIM : 605821
UniProt ID : Q9NZD4
Chromosome Location : 16p11.1
Function : hemoglobin binding; unfolded protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What techniques are used to quantify the binding affinity between Ahsp and alpha-globin? 04/25/2022

echniques such as isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) are commonly employed to quantify the binding affinity and kinetics of Ahsp-alpha-globin interactions.

What is the connection between Ahsp and hemoglobinopathies? 01/20/2022

Ahsp deficiency can lead to unstable alpha-globin chains, contributing to the development of certain hemoglobinopathies like alpha-thalassemia.

How does Ahsp respond to cellular stress conditions? 11/17/2021

Ahsp expression may be upregulated during cellular stress to enhance its protective role in stabilizing alpha-globin chains and preventing protein aggregation.

What techniques are commonly used to study the interactions of Ahsp with alpha-globin chains? 03/09/2021

Techniques such as nuclear magnetic resonance (NMR), X-ray crystallography, and molecular dynamics simulations are commonly used to study protein-protein interactions involving Ahsp and alpha-globin.

How does Ahsp interact with chaperone proteins in the cell? 10/31/2020

Ahsp can interact with molecular chaperones like Hsp70 to assist in protein folding and prevent misfolding of alpha-globin chains.

How does Ahsp achieve its stabilizing function at the molecular level? 06/15/2020

Ahsp binds to free alpha-globin chains, preventing their aggregation and degradation by maintaining their folded state.

What is the significance of Ahsp in preventing thalassemia? 09/28/2019

Ahsp plays a role in preventing excess alpha-globin chains from aggregating and precipitating, which is a key factor in the pathogenesis of alpha-thalassemia.

How does Ahsp's function compare to other molecular chaperones in the cell? 07/12/2019

Ahsp's role is unique, focusing specifically on stabilizing alpha-globin chains, whereas other chaperones have broader functions in assisting protein folding and transport.

Can you explain the role of Ahsp in the context of iron metabolism? 12/04/2018

Ahsp indirectly influences iron metabolism by stabilizing alpha-globin chains and preventing their degradation, which in turn maintains balanced globin chain production and minimizes iron waste.

How does Ahsp contribute to maintaining red blood cell stability and lifespan? 09/03/2018

Ahsp's role in stabilizing alpha-globin chains helps prevent the formation of toxic aggregates that could damage red blood cells and shorten their lifespan.

Customer Reviews (5)

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Reviews
05/13/2022

    Outstanding product supplement. Worth every penny and arrived ahead of schedule.

    03/02/2021

      Top-notch lab protein for a fraction of the cost. Superb value for money.

      07/06/2020

        Great protein quality at an affordable price. Impressed with the results!

        12/27/2019

          Exceptional quality product that doesn't break the bank. Fast delivery too!

          09/18/2018

            This protein product is a game-changer – premium quality and budget-friendly.

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