Recombinant Human TTPA Protein, His-SUMO-tagged

• Cat.No.: TTPA-3400H
• Product Overview: Recombinant Human TTPA protein(NP_000361.1)(1-278aa) was expressed in E.coli with two N-terminal tag, His tag and SUMO tag.

Specification

• Description: This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 47.7kDa
• Protein length: 1-278aa
• AA Sequence: MAEARSQPSAGPQLNALPDHSPLLQ PGLAALRRRAREAGVPLAPLPLTDS FLLRFLRARDFDLDLAWRLLKNYYK WRAECPEISADLHPRSIIGLLKAGY HGVLRSRDPTGSKVLIYRIAHWDPK VFTAYDVFRVSLITSELIVQEVETQ RNGIKAIFDLEGWQFSHAFQITPSV AKKIAAVLTDSFPLKVRGIHLINEP VIFHAVFSMIKPFLTEKIKERIHMH GNNYKQSLLQHFPDILPLEYGGEEF SMEDICQEWTNFIMKSEDYLSSISE SIQ
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Gene Information

• Gene Name: TTPA alpha tocopherol transfer protein [ Homo sapiens (human) ]
• Official Symbol: TTPA
• Synonyms: Alpha-tocopherol transfer protein; Alpha-TTP; AlphaTTP; ATTP; AVED; Tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency); TTP1; TTPA; TTPA_HUMAN
• Gene ID: 7274
• mRNA Refseq: NM_000370.3
• Protein Refseq: NP_000361.1
• MIM: 600415
• UniProt ID: P49638