Native Human ApoE

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Native Human ApoE

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Cat.No. : ApoE-3560H
Description : Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Source : Human plasma
Species : Human
Form : Supplied in 50mM NH4HCO3, pH 8.0.
Molecular Mass : 34 kDa
Purity : >95% pure by SDS PAGE
Notes : Small volumes of ApoE native protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Aliquot and store at -70 deg C or lower. Avoid repeated freeze/thaw cycles.
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : APOE apolipoprotein E [ Homo sapiens ]
Official Symbol : APOE
Synonyms : APOE; apolipoprotein E; AD2, Alzheimer disease 2 (APOE*E4 associated, late onset); apo-E; apolipoprotein E3; AD2; LPG; LDLCQ5; MGC1571;
Gene ID : 348
mRNA Refseq : NM_000041
Protein Refseq : NP_000032
UniProt ID : P02649
Chromosome Location : 19q13.31
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Chylomicron-mediated lipid transport, organism-specific biosystem; HDL-mediated lipid transport, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem; Lipoprotein metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function : antioxidant activity; beta-amyloid binding; cholesterol transporter activity; heparin binding; identical protein binding; lipid binding; lipid transporter activity; lipoprotein particle binding; low-density lipoprotein particle receptor binding; low-density lipoprotein particle receptor binding; metal chelating activity; phosphatidylcholine-sterol O-acyltransferase activator activity; phospholipid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; tau protein binding; very-low-density lipoprotein particle receptor binding; very-low-density lipoprotein particle receptor binding;

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