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Recombinant Human ALOX12B, His-tagged

Cat.No. : ALOX12B-3608H
Product Overview : Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
Source : E. Coli or Yeast
Species : Human
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 701
Purity : >90%
Notes : Small volumes of ALOX12B recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : ALOX12B arachidonate 12-lipoxygenase, 12R type [ Homo sapiens ]
Official Symbol : ALOX12B
Synonyms : ALOX12B; arachidonate 12-lipoxygenase, 12R type; arachidonate 12-lipoxygenase, 12R-type; 12R LOX; 12R-lipoxygenase; epidermis-type lipoxygenase 12; 12R-LOX;
Gene ID : 242
mRNA Refseq : NM_001139
Protein Refseq : NP_001130
MIM : 603741
UniProt ID : O75342
Chromosome Location : 17p13.1
Pathway : Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Serotonergic synapse, organism-specif
Function : arachidonate 12-lipoxygenase activity; iron ion binding; lipoxygenase activity; metal ion binding; oxidoreductase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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How does ALOX12B gene mutation affect cardiovascular health? 02/22/2023

Mutations in the ALOX12B gene may lead to the development of cardiovascular disease, which can affect cardiovascular health.

Are ALOX12B gene variants associated with tumors? 02/20/2023

The ALOX12B gene variant has not been shown to be associated with tumors.

Based on the mutation of ALOX12B gene, is there an effective treatment at present? 12/18/2022

There is no specific treatment for the ALOX12B gene mutation. Treatment is mostly based on symptom relief and reduction of disease progression.

How is the ALOX12B gene mutant diagnosed? 08/02/2022

A mutation of the ALOX12B gene can be diagnosed with a genetic test or blood test.

What is the regulatory mechanism of ALOX12B gene? 05/12/2021

The regulatory mechanisms of ALOX12B gene include transcription factors, miRNA and other regulatory mechanisms.

Does ALOX12B gene mutation have an impact on skin health? 04/18/2021

Mutations in the ALOX12B gene may lead to the development of skin diseases that affect skin health.

Does ALOX12B gene mutation cause liver disease? 02/24/2021

ALOX12B gene mutation and liver disease has not been proven to have a clear link.

In which populations is the ALOX12B gene most common? 10/11/2020

Current studies have shown that the ALOX12B variant is more common in Asian populations.

What is the function of the ALOX12B gene? 08/23/2020

ALOX12B encodes the 12R-LOX enzyme, which is involved in biological processes such as lipid metabolism and inflammatory responses.

How do polymorphisms in the ALOX12B gene affect its function? 06/20/2020

The polymorphism of ALOX12B gene can affect the activity of the enzyme it encodes, and thus affect related biological processes.

Is the SNP of ALOX12B gene related to drug metabolism? 03/08/2020

The SNP of ALOX12B gene has not been confirmed to have a clear association with drug metabolism.

Does ALOX12B affect the immune system? 12/09/2019

The ALOX12B gene plays an important role in the body's inflammatory response and therefore may influence the function of the immune system.

Which diseases are related to the expression of ALOX12B gene? 09/26/2019

Mutations in the ALOX12B gene have been linked to skin disorders, asthma, cardiovascular disease and more.

Does ALOX12B gene affect body metabolism? 09/09/2019

The ALOX12B gene can affect biological processes such as fat metabolism in the body, thus affecting body metabolism.

Which diseases are the ALOX12B gene mutations clearly associated with? 07/01/2019

A mutant version of the ALOX12B gene has been linked to a rare inherited fat metabolism disorder called Allen's syndrome.

In which organs is ALOX12B gene more expressed? 06/24/2019

ALOX12B gene is more expressed in skin, liver, heart, kidney and other organs.

Customer Reviews (3)

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Reviews
06/22/2022

    ALOX12B has good absorbability and high bioavailability.

    01/29/2021

      Highly effective in signal transduction pathways.

      08/20/2020

        Under different environmental conditions,ALOX12B showed good stability.

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