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Recombinant Rat Atxn3, His-tagged

Cat.No. : Atxn3-3689R
Product Overview : Ataxin-3 (Atxn3)
  • Specification
  • Gene Information
  • Related Products
Description : gene associated with spinocerebellar ataxia type 3 .
Source : E. Coli or Yeast
Species : Rat
Tag : His
Form : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Protein length : 355
Purity : >90%
Notes : Small volumes of Atxn3 recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Storage : Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Storage Buffer : PBS pH 7.4, 50% glycerol
Warning : This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name : Atxn3 ataxin 3 [ Rattus norvegicus ]
Official Symbol : Atxn3
Synonyms : ATXN3; ataxin 3; ataxin-3; machado-Joseph disease protein 1 homolog; Rsca3;
Gene ID : 60331
mRNA Refseq : NM_021702
Protein Refseq : NP_067734
Chromosome Location : 6q32
Pathway : Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem;
Function : cysteine-type peptidase activity; molecular_function; omega peptidase activity; peptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What are the clinical manifestations of SCA3? 10/15/2022

The clinical manifestations of SCA3 include ataxia (especially limb motor coordination disorder), myoclonus, ocular muscle movement abnormalities, extrapyramidal symptoms, dysphagia, language disorder, etc. As the disease progresses, patients have more and more significant difficulties with walking, balance, and other movements.

Which cellular processes are ATXN3 proteins involved in? 02/23/2022

ATXN3 protein is involved in many important cellular processes, including protein degradation, cell signaling, apoptosis, RNA metabolism, etc. It plays an important role in the regulation of cellular functions.

Is there any treatment for SCA3? 07/09/2021

At present, there is no cure for SCA3, but some adjuvant therapies can be used to improve symptoms. Physical therapy, speech therapy and swallowing function training can improve the quality of life of patients. In addition, there are some studies on protein degradation pathways for abnormal aggregation of ATXN3 protein, but they are still in the experimental stage.

Is ATXN3 protein associated with other diseases? 03/23/2021

In addition to its association with SCA3, ATXN3 protein may also be associated with some other diseases. For example, studies have shown that ATXN3 protein is related to the occurrence and development of neurodegenerative diseases such as Parkinson's disease and Huntington's disease, but the specific mechanism needs to be further studied and verified.

How do ATXN3 protein abnormalities cause SCA3? 07/06/2020

SCA3 is caused by mutations in the ATXN3 gene that lead to excessive repeat of polyglutamine (PolyQ) sequences in ATXN3 protein. This abnormal expansion will cause abnormal ATXN3 protein folding and aggregation, leading to impaired cell function and eventually triggering SCA3 symptoms.

Which disease is ATXN3 protein associated with? 11/26/2019

ATXN3 protein is associated with autodominant genetic disease Spinocerebellar Ataxia Type 3 (SCA3). SCA3 is a neurodegenerative disease characterized by ataxia, extrapyramidal symptoms, and motor neuron dysfunction.

Customer Reviews (3)

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Reviews
06/21/2021

    ATXN3 is very catalytic active and shows excellent catalytic performance even at low concentrations.

    08/14/2019

      ATXN3 detection method is sensitive and can detect trace amounts of protein, which is well suited for our study.

      03/25/2019

        Using ATXN3, the reproducibility of my experiments is very good, which facilitates subsequent data analysis and experimental manipulation.

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