"MMP2" Related Products

Recombinant Human MMP2, GST-tagged

Cat.No.: MMP2-8392H
Product Overview: Recombinant Human MMP2 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: 461-660aa
Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [ Homo sapiens ]
Official Symbol: MMP2
Synonyms: MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); MONA; CLG4A; TBE-1; MMP-II; matrix metalloproteinase 2; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-II; CLG4; EC 3.4.24.24; Matrix metalloproteinase-2; MMP-2; Gelatinase A
Gene ID: 4313
mRNA Refseq: NM_001127891
Protein Refseq: NP_001121363
MIM: 120360
UniProt ID: P08253
Chromosome Location: 16q13-q21
Pathway: ATF-2 transcription factor network; Angiopoietin receptor Tie2-mediated signaling; Bladder cancer; Diabetes pathways; GnRH signaling pathway; IL-3 Signaling Pathway; LPA receptor mediated events;
Function: metal ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

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