Recombinant Human RIPK1, GST-tagged

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Recombinant Human RIPK1, GST-tagged

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Cat.No. : RIPK1-36H
Product Overview : Full-length recombinant human RIPK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process. TNFalpha is capable of activating the noncanonical NF-kB pathway, but this activation of this pathway is negatively regulated by RIPK1.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 3.5 nmol/min/mg
Molecular Mass : ~108 kDa
Applications : Kinase Assay, Western Blot
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.05ug/ul
Gene Name : RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 [ Homo sapiens ]
Official Symbol : RIPK1
Synonyms : RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; serine/threonine-protein kinase RIP; RIP1; FLJ39204;
Gene ID : 8737
mRNA Refseq : NM_003804
Protein Refseq : NP_003795
MIM : 603453
UniProt ID : Q13546
Chromosome Location : 6p25.2
Pathway : Activated TLR4 signalling, organism-specific biosystem; Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem;
Function : ATP binding; death domain binding; death receptor binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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