Recombinant Human ALK2 Mutant (Q207E), GST-tagged ACVR1-38H

Recombinant Human ALK2 Mutant (Q207E), GST-tagged

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Recombinant Human ALK2 Mutant (Q207E), GST-tagged

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Cat.No. : ACVR1-38H
Product Overview : Recombinant human ALK2 (Q207E) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFbetaRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells . Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues.
Source : Sf9 insect cells using baculovirus
Species : Human
Tag : GST
Form : 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 23 nmol/min/mg
Molecular Mass : ~67 kDa
Applications : Kinase Assay
Storage : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration : 0.1ug/ul
Gene Name : ACVR1 activin A receptor, type I [ Homo sapiens ]
Official Symbol : ACVR1
Synonyms : ACVR1; activin A receptor, type I; OTTHUMP00000204604; OTTHUMP00000204626; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; activin receptor type I; activin receptor type-1; activin receptor-like kinase 2; hydroxyalkyl-protein kinase; serine/threonine-protein kinase receptor R1; EC 2.7.11.30
Gene ID : 90
mRNA Refseq : NM_001105
Protein Refseq : NP_001096
MIM : 102576
UniProt ID : Q04771
Chromosome Location : 2q23-q24
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : ATP binding; contributes_to activin receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity; transforming growth factor beta binding; protein homodimerization activity

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