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Recombinant Human CD276, MIgG2a Fc-tagged

Cat.No.: CD276-2001H
Product Overview: The extracellular domain of human B7-H3 (NP_079516.1) (Leu29-Pro245) is fused to the N-terminus of the Fc region of mouse IgG2a.
Description: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3" UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source: CHO cells
Species: Human
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Molecular Mass: 49KDa (monomer)
AA Sequence: Leu29-Pro245
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: CD276 CD276 molecule [ Homo sapiens ]
Official Symbol: CD276
Synonyms: CD276; CD276 molecule; CD276 antigen; B7 H3; B7H3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3;
Gene ID: 80381
mRNA Refseq: NM_001024736
Protein Refseq: NP_001019907
MIM: 605715
UniProt ID: Q5ZPR3
Chromosome Location: 15q23-q24
Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem;
Function: protein binding; receptor binding;

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