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Recombinant Human CYP1A2

Cat.No. : CYP1A2-551H
Product Overview : Recombinant Human Cytochrome P450 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5 was expressed in baculovirus infected insect cells. Microsomes containing recombinant human CYP1A2, recombinant rabbit NADPH-P450 reductase, and cytochrome b5.
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  • Gene Information
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme"s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3" untranslated region.
Source : baculovirus infected insect cells
Species : Human
Form : Solution in 100 mM potassium phosphate buffer, pH 7.4.
Applications : Human cytochrome P450 has been used in a study to investigate non-viral environmental risk factors for nasopharyngeal carcinoma. Human cytochrome P450 has also been used in a study to investigate the dynamics and hydration of the active sites of mammalian cytochromes.
Storage : ?70°C
Gene Name : CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [ Homo sapiens (human) ]
Official Symbol : CYP1A2
Synonyms : CYP1A2; CP12; P3-450; P450(PA); cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450 1A2; CYPIA2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; NP_000752.2; EC 1.14.14.1
Gene ID : 1544
mRNA Refseq : NM_000761
Protein Refseq : NP_000752
MIM : 124060
UniProt ID : P05177
Chromosome Location : 15q24.1
Pathway : Aflatoxin B1 metabolism; Biological oxidations; Caffeine metabolism
Function : aromatase activity; heme binding; iron ion binding

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◆ Lysates
CYP1A2-432HCL Recombinant Human CYP1A2 cell lysate +Inquiry

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◆ Assay kits
Kit-2126 Cytochrome P450 1A2 Fluorometric Activity Assay Kit +Inquiry
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CYP1A2 interact with other cytochrome P450 enzymes in metabolic pathways? 12/29/2022

CYP1A2 collaborates with other P450 enzymes in metabolic processes.

What is the impact of altered CYP1A2 activity on liver function and disease risk? 10/20/2022

Changes in CYP1A2 activity can affect liver health and disease risk.

How do genetic variations in CYP1A2 affect drug metabolism and response? 09/23/2021

Genetic differences in CYP1A2 influence drug metabolism and individual medication responses.

What is the primary role of CYP1A2 in xenobiotic metabolism? 09/06/2021

CYP1A2 is key in metabolizing drugs and environmental chemicals.

What role does CYP1A2 play in the detoxification of environmental toxins? 01/29/2020

CYP1A2 helps detoxify harmful environmental substances.

How does CYP1A2 contribute to the metabolism of caffeine and other dietary compounds? 06/08/2019

It metabolizes caffeine and certain dietary compounds, affecting their bodily impact.

What potential therapeutic applications arise from understanding CYP1A2 activity in personalized medicine? 08/11/2017

CYP1A2's role can inform personalized medicine, tailoring drug therapies to individual metabolic profiles.

Customer Reviews (3)

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Reviews
10/15/2022

    Enables data-driven decisions. Elevates research standards.

    08/02/2021

      Invaluable for insights. Highly recommended for research.

      10/23/2020

        Swift and accurate service. Supports research credibility.

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