Recombinant Human CYP1A2
Cat.No. : | CYP1A2-551H |
Product Overview : | Recombinant Human Cytochrome P450 1A2 Isozyme Microsomes, with P450 Reductase and cytochrome b5 was expressed in baculovirus infected insect cells. Microsomes containing recombinant human CYP1A2, recombinant rabbit NADPH-P450 reductase, and cytochrome b5. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme"s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3" untranslated region. |
Source : | baculovirus infected insect cells |
Species : | Human |
Form : | Solution in 100 mM potassium phosphate buffer, pH 7.4. |
Applications : | Human cytochrome P450 has been used in a study to investigate non-viral environmental risk factors for nasopharyngeal carcinoma. Human cytochrome P450 has also been used in a study to investigate the dynamics and hydration of the active sites of mammalian cytochromes. |
Storage : | ?70°C |
Gene Name : | CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [ Homo sapiens (human) ] |
Official Symbol : | CYP1A2 |
Synonyms : | CYP1A2; CP12; P3-450; P450(PA); cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450 1A2; CYPIA2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; NP_000752.2; EC 1.14.14.1 |
Gene ID : | 1544 |
mRNA Refseq : | NM_000761 |
Protein Refseq : | NP_000752 |
MIM : | 124060 |
UniProt ID : | P05177 |
Chromosome Location : | 15q24.1 |
Pathway : | Aflatoxin B1 metabolism; Biological oxidations; Caffeine metabolism |
Function : | aromatase activity; heme binding; iron ion binding |
Products Types
◆ Recombinant Protein | ||
CYP1A2-119D | Active Recombinant Dog CYP1A2 Protein | +Inquiry |
CYP1A2-2796H | Recombinant Human CYP1A2 Protein, His-tagged, OVA Conjugated | +Inquiry |
CYP1A2-132P | Active Recombinant Pig CYP1A2 Protein | +Inquiry |
CYP1A2-1297H | Recombinant Human CYP1A2 Protein, His&GST-tagged | +Inquiry |
Cyp1a2-141R | Recombinant Rat CYP1A2 Protein | +Inquiry |
◆ Lysates | ||
CYP1A2-432HCL | Recombinant Human CYP1A2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-2126 | Cytochrome P450 1A2 Fluorometric Activity Assay Kit | +Inquiry |
Kit-2127 | Cytochrome P450 1A2 Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionCYP1A2 collaborates with other P450 enzymes in metabolic processes.
Changes in CYP1A2 activity can affect liver health and disease risk.
Genetic differences in CYP1A2 influence drug metabolism and individual medication responses.
CYP1A2 is key in metabolizing drugs and environmental chemicals.
CYP1A2 helps detoxify harmful environmental substances.
It metabolizes caffeine and certain dietary compounds, affecting their bodily impact.
CYP1A2's role can inform personalized medicine, tailoring drug therapies to individual metabolic profiles.
Customer Reviews (3)
Write a reviewEnables data-driven decisions. Elevates research standards.
Invaluable for insights. Highly recommended for research.
Swift and accurate service. Supports research credibility.
Ask a Question for All CYP1A2 Products
Required fields are marked with *
My Review for All CYP1A2 Products
Required fields are marked with *
Inquiry Basket