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Native Human Renin Antigen

Cat.No.: REN-388H
Product Overview: Native Human Renin Antigen was purified from Human Kidney.
Description: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Source: Human Kidney
Species: Human
Form: Clear, colorless liquid. Liquid in sodium acetate, EDTA and benzamidine, pH 6.0.
Bio-activity: Typically >1 U/mL
Purity: >90% (Electrophoresis)
Unit Definition: Renin Activity was measured by following the cleavage of the fluorogenic substrate Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(dabcyl)-Arg at pH 8.0 and 37C.
Storage: 2-8 °C
Concentration: Protein: >0.1 mg protein/mL (Lowry)
Gene Name: REN renin [ Homo sapiens ]
Official Symbol: REN
Synonyms: REN; renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme; HNFJ2; FLJ10761;
Gene ID: 5972
mRNA Refseq: NM_000537
Protein Refseq: NP_000528
MIM: 179820
UniProt ID: P00797
Chromosome Location: 1q32
Pathway: ACE Inhibitor Pathway, organism-specific biosystem; Renin-angiotensin system, organism-specific biosystem; Renin-angiotensin system, conserved biosystem;
Function: aspartic-type endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding;

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