Active Recombinant Human GBA, His-tagged
Cat.No. : | GBA-22H |
Product Overview : | Recombinant Human GBA, fused with C-terminal 6-His tag, was expressed in CHO Cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. |
Source : | CHO Cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Ala40 |
Form : | Supplied as a 0.2 μm filtered solution in Tris, NaCl, Glycerol and DTT. |
Bio-activity : | Measured by its ability to hydrolyze 4-methylumbelliferyl-beta-D-glucopyranoside. |
Molecular Mass : | Predicted Molecular Mass: 56 kDaSDS-PAGE: 58-75 kDa, reducing conditions |
Endotoxin : | < 1.0 eu per 1 μg of the protein by the lal |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane. |
Storage : | Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 °C as supplied.3 months, -70 °C under sterile conditions after opening. |
Gene Name : | GBA glucosidase, beta, acid [ Homo sapiens ] |
Official Symbol : | GBA |
Synonyms : | GBA; GCB; GBA1; GLUC; glucosidase, beta, acid; glucosylceramidase; beta-GC; alglucerase; imiglucerase; acid beta-glucosidase; beta-glucocerebrosidase; lysosomal glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase; NP_000148.2; EC 3.2.1.45; NP_001005741.1; NP_001005742.1; NP_001165282.1; NP_001165283.1 |
Gene ID : | 2629 |
mRNA Refseq : | NM_000157 |
Protein Refseq : | NP_000148 |
MIM : | 606463 |
UniProt ID : | P04062 |
Chromosome Location : | 1q21 |
Pathway : | Glycosphingolipid metabolism; Other glycan degradation; Sphingolipid metabolism |
Function : | glucosylceramidase activity; protein binding; receptor binding |
Products Types
◆ Recombinant Protein | ||
GBA-4764H | Recombinant Human GBA Protein, GST-tagged | +Inquiry |
GBA-539H | Recombinant Human GBA Protein (Ala40-Gln536), His-tagged | +Inquiry |
Gba-3165M | Recombinant Mouse Gba Protein, Myc/DDK-tagged | +Inquiry |
GBA-3492M | Recombinant Mouse GBA Protein, His (Fc)-Avi-tagged | +Inquiry |
GBA-020H | Active Recombinant Human GBA, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
GBA-6002HCL | Recombinant Human GBA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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