Active Recombinant Human TPM3, GST-tagged

• Cat.No.: TPM3-94H
• Product Overview: Recombinant human fusion protein TPM3 (1-258)-TRKA (399-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family which is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TRKA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermoregulation via sweating in humans. The oncogenic rearrangement of 5′TPM3-3′NTRK1 fusion gene has been found in papillary thyroid carcinomas.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Bio-activity: 12 nmol/min/mg
• Molecular Mass: ~105 kDa
• Purity: >70% by densitometry
• Applications: Kinase Assay
• Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.05 ug/ul

Gene Information

• Gene Name: TPM3 tropomyosin 3 [ Homo sapiens ]
• Official Symbol: TPM3
• Synonyms: TPM3; tropomyosin 3; NEM1; tropomyosin alpha-3 chain; TRK; tropomyosin-3; tropomyosin-5; gamma-tropomyosin; tropomyosin gamma; cytoskeletal tropomyosin TM30; heat-stable cytoskeletal protein 30 kDa; TM3; TM5; CFTD; TM-5; TM30; hTM5; TM30nm; TPMsk3; hscp30; OK/SW-cl.5; MGC3261; FLJ41118; MGC14582; MGC72094
• Gene ID: 7170
• mRNA Refseq: NM_001043351
• Protein Refseq: NP_001036816
• MIM: 191030
• UniProt ID: P06753
• Chromosome Location: 1q21.2
• Pathway: Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem; Hypertrophic cardiomyopathy (HCM), organism-specific biosystem; Hypertrophic cardiomyopathy (HCM), conserved biosystem; Muscle contraction, organism-specific biosystem
• Function: actin binding; molecular_function