Cat. No.:	PCMT1-704H
Product Overview:	Recombinant human PCMT1 protien, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 28.8 kDa (263aa).
Description:	PCMT1, also known as L-isoaspartyl protein carboxyl methyltransferase, is an enzyme that catalyses the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. This protein plays a role in the repair and/or degradation of damaged proteins.
Source:	E.coli.
Form:	Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl.
Purity:	> 95% by SDS – PAGE.
Concentration:	1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids:	MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAWK SGGASHSELI HNLRKNGIIK TDKVFEVMLA TDRSHYAKCN PYMDSPQSIG FQATISAPHM HAYALELLFD QLHEGAKALD VGSGSGILTA CFARMVGCTG KVIGIDHIKE LVDDSINNVR KDDPTLLSSG RVQLVVGDGR MGYAEEAPYD AIHVGAAAPV VPQALIDQLK PGGRLILPVG PAGGNQMLEQ YDKLQDGSIK MKPLMGVIYV PLTDKEKQWS RWK.
Storage:	can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Name:	PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase [ Homo sapiens ]
Synonyms:	protein-L-isoaspartate (D-aspartate) O-methyltransferase; PCMT1; protein-L-isoaspartate(D-aspartate) O-methyltransferase; PIMT; OTTHUMP00000017397; OTTHUMP00000017398; OTTHUMP00000017400; protein-beta-aspartate methyltransferase; L-isoaspartyl/D-aspartyl methyltransferase; L-isoaspartyl protein carboxyl methyltransferase; protein L-isoaspartyl/D-aspartyl methyltransferase;protein-L-isoaspartate (D-aspartate) O-methyltransferase 1; Protein-beta-aspartate methyltransferase; Protein L-isoaspartyl/D-aspartyl methyltransferase; EC 2.1.1.77
Gene ID:	5110
mRNA Refseq:	NM_005389
Protein Refseq:	NP_005380
MIM:	176851
UniProt ID:	P22061
Chromosome Location:	6q24-q25
Function:	identical protein binding; methyltransferase activity; protein binding; transferase activity; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

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