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Active Recombinant Human IGFBP1 Protein

Cat.No. : IGFBP1-79H
Product Overview : Recombinant human IGFBP1 protein (Ala26-Asn259) without tag was expressed in mouse myeloma cell line.
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  • Gene Information
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Description : This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients.
Source : Mammalian cells
Species : Human
Bio-activity : Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF‑7 human breast cancer cells. The ED50 for this effect is typically 0.1-0.6 μg/mL in the presence of 6 ng/mL recombinant human IGF-I.
Molecular Mass : 25 kDa
N-terminal Sequence Analysis : Ala26
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Gene Name : IGFBP1 insulin like growth factor binding protein 1 [ Homo sapiens (human) ]
Official Symbol : IGFBP1
Synonyms : alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; hIGFBP-1; IBP1; IBP-1; IGF-binding protein 1; IGFBP1; IGFBP-1; IGF-BP25; insulin-like growth factor binding protein 1; insulin-like growth factor-binding protein 1; Placental protein 12; PP12AFBP
Gene ID : 3484
mRNA Refseq : NM_000596
Protein Refseq : NP_000587
MIM : 146730
UniProt ID : P08833

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does IGFBP1 contribute to the development and progression of cancers, especially hormone-dependent cancers? 05/02/2022

IGFBP1 influences the progression of certain cancers, particularly those sensitive to hormonal regulation.

How do changes in IGFBP1 expression affect aging and age-related diseases? 12/17/2021

Changes in IGFBP1 expression contribute to the aging process and the development of age-related diseases.

What is the impact of IGFBP1 on fetal growth and development during pregnancy? 12/19/2020

IGFBP1 is important for fetal growth and development, regulating growth factor activity during pregnancy.

How does IGFBP1 influence muscle growth and regeneration, particularly in muscle-wasting conditions? 01/10/2020

IGFBP1 affects muscle growth and regeneration, playing a role in conditions involving muscle wasting.

What are the effects of IGFBP1 on cardiovascular health and diseases such as atherosclerosis? 08/09/2019

IGFBP1 impacts cardiovascular health, influencing factors like blood vessel growth and atherosclerosis development.

What role does IGFBP1 play in metabolic processes, particularly in glucose homeostasis and insulin sensitivity? 01/20/2018

IGFBP1 plays a crucial role in glucose metabolism and insulin sensitivity, impacting overall metabolic health.

How does IGFBP1 regulate the activity of insulin-like growth factors (IGFs) in different tissues? 01/15/2018

IGFBP1 modulates the availability and activity of IGFs, affecting growth and metabolic functions in various tissues.

Customer Reviews (3)

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Reviews
06/13/2022

    Precise antibody validation, enhances immunoprecipitation studies.

    03/12/2019

      Efficient protein purification, delivers high yield and purity.

      06/25/2018

        Dependable expertise in protein engineering, unmatched quality.

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