Recombinant Human MASP1, GST-tagged
Cat.No. : | MASP1-755H |
Product Overview : | Recombinant Human MASP1(1 a.a. - 380 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants. |
Source : | Wheat germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 70 kDa |
AA Sequence : | MRWLLLYYALCFSLSKASAHTVELN NMFGQIQSPGYPDSYPSDSEVTWNI TVPDGFRIKLYFMHFNLESSYLCEY DYVKVETEDQVLATFCGRETTDTEQ TPGQEVVLSPGSFMSITFRSDFSNE ERFTGFDAHYMAVDVDECKEREDEE LSCDHYCHNYIGGYYCSCRFGYILH TDNRTCRVECSDNLFTQRTGVITSP DFPNPYPKSSECLYTIELEEGFMVN LQFEDIFDIEDHPEVPCPYDYIKIK VGPKVLGPFCGEKAPEPISTQSHSV LILFHSDNSGENRGWRLSYRAAGNE CPELQPPVHGKIEPSQAKYFFKDQV LVSCDTGYKVLKDNVEMDTFQIECL KDGTWSNKIPTCKKNEIDLESELKS EQVTE |
Applications : | ELISA; WB-Re; AP; Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) [ Homo sapiens (human) ] |
Official Symbol : | MASP1 |
Synonyms : | MASP1; 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1; mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor); mannan-binding lectin serine protease 1; serine protease 5; complement factor MASP-3; Ra-reactive factor serine protease p100; mannose-binding protein-associated serine protease; mannose-binding lectin-associated serine protease 1; complement-activating component of Ra-reactive factor; EC 3.4.21.- |
Gene ID : | 5648 |
mRNA Refseq : | NM_001031849 |
Protein Refseq : | NP_001027019 |
MIM : | 600521 |
UniProt ID : | P48740 |
Chromosome Location : | 3q27-q28 |
Pathway : | Binding and Uptake of Ligands by Scavenger Receptors; Complement Activation; Complement and coagulation cascades |
Function : | calcium ion binding; calcium-dependent protein binding; peptidase activity |
Products Types
◆ Recombinant Protein | ||
Masp1-3966M | Recombinant Mouse Masp1 Protein, Myc/DDK-tagged | +Inquiry |
MASP1-1372H | Recombinant Human MASP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MASP1-1451H | Recombinant Human MASP1 Protein (20-699 aa), His-tagged | +Inquiry |
MASP1-5379M | Recombinant Mouse MASP1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MASP1-02H | Recombinant Human MASP1 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
MASP1-4461HCL | Recombinant Human MASP1 293 Cell Lysate | +Inquiry |
MASP1-4460HCL | Recombinant Human MASP1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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