Recombinant Human CXCR4

• Cat.No.: CXCR4-504H
• Product Overview: Recombinant Human CXCR4 was expressed in wheat germ.

Specification

• Description: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: Wheat germ
• Species: Human
• Form: Liquid
• Molecular Mass: 39.7 kDa
• AA Sequence: MEGISIYTSDNYTEEMGSGDYDSMK EPCFREENANFNKIFLPTIYSIIFL TGIVGNGLVILVMGYQKKLRSMTDK YRLHLSVADLLFVITLPFWAVDAVA NWYFGNFLCKAVHVIYTVNLYSSVL ILAFISLDRYLAIVHATNSQRPRKL LAEKVVYVGVWIPALLLTIPDFIFA NVSEADDRYICDRFYPNDLWVVVFQ FQHIMVGLILPGIVILSCYCIIISK LSHSKGHQKRKALKTTVILILAFFA CWLPYYIGISIDSFILLEIIKQGCE FENTVHKWISITEALAFFHCCLNPI LYAFLGAKFKTSAQHALTSVSRGSS LKILSKGKRGGHSSVSTESESSSFH SS
• Applications: Antibody Production; Functional Study; Compound Screening
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH 8.0 containing 2% glycerol.
• Publication:
  The development and characterization of SDF1α-elastin-like-peptide nanoparticles for wound healing (2016)

Gene Information

• Gene Name: CXCR4 chemokine (C-X-C motif) receptor 4 [ Homo sapiens ]
• Official Symbol: CXCR4
• Synonyms: CXCR4; chemokine (C-X-C motif) receptor 4; chemokine (C X C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CD184; D2S201E; fusin; HM89; HSY3RR; LESTR; NPY3R; NPYR; NPYY3R; CXC-R4; CXCR-4; CD184 antigen; SDF-1 receptor; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; FB22; LAP3; LCR1; WHIM; NPYRL
• Gene ID: 7852
• mRNA Refseq: NM_001008540
• Protein Refseq: NP_001008540
• MIM: 162643
• UniProt ID: P61073
• Chromosome Location: 2q21
• Pathway: Axon guidance; Cardiac Progenitor Differentiation; Class A/1 (Rhodopsin-like receptors)
• Function: C-X-C chemokine receptor activity; G-protein coupled receptor activity; myosin light chain binding