Recombinant Human CXCR4 protein, His-tagged

• Cat.No.: CXCR4-510H
• Product Overview: Recombinant Human CXCR4 protein (Asp262-Ser352) was fused to His-tag at N-terminus and expressed in E.coli.

Specification

• Description: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: E.coli
• Species: Human
• Tag: His
• Form: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Molecular Mass: 16 kDa as determined by SDS-PAGE reducing conditions.
• Protein length: 91
• AA Sequence: DSFILLEIIKQGCEFENTVHKWISI TEALAFFHCCLNPILYAFLGAKFKT SAQHALTSVSRGSSLKILSKGKRGG HSSVSTESESSSFHSS
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: >90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: CXCR4
• Official Symbol: CXCR4
• Synonyms: FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; D2S201E; Fusin; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide-associated protein 3
• Gene ID: 7852
• mRNA Refseq: NM_001008540.2
• Protein Refseq: NP_001008540.1
• MIM: 162643
• UniProt ID: P61073