Recombinant Human APC cell lysate


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Recombinant Human APC cell lysate

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Cat.No. : APC-90HCL
Description : This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : APC adenomatous polyposis coli [ Homo sapiens ]
Official Symbol : APC
Synonyms : APC; adenomatous polyposis coli; adenomatosis polyposis coli; adenomatous polyposis coli protein; DP2; DP2.5; DP3; PPP1R46; protein phosphatase 1; regulatory subunit 46; deleted in polyposis 2.5; adenomatosis polyposis coli tumor suppressor; protein phosphatase 1, regulatory subunit 46; GS; BTPS2;
Gene ID : 324
mRNA Refseq : NM_000038
Protein Refseq : NP_000029
MIM : 611731
UniProt ID : P25054
Chromosome Location : 5q21-q22
Pathway : Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Beta-catenin phosphorylation cascade, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem;
Function : beta-catenin binding; NOT cadherin binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity;

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