Recombinant Human ARHGEF6 cell lysate

• Cat.No.: ARHGEF6-119HCL

Specification

• Description: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 [ Homo sapiens ]
• Official Symbol: ARHGEF6
• Synonyms: ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6; mental retardation, X linked 46 , MRX46; rho guanine nucleotide exchange factor 6; alpha PIX; alphaPIX; Cool 2; Cool2; KIAA0006; PAK interacting exchange factor; alpha; Rac/Cdc42 guanine exchange factor (GEF) 6; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; rac/Cdc42 guanine nucleotide exchange factor 6; PIXA; COOL2; MRX46; Cool-2; alpha-PIX
• Gene ID: 9459
• mRNA Refseq: NM_004840
• Protein Refseq: NP_004831
• MIM: 300267
• UniProt ID: Q15052
• Chromosome Location: Xq26
• Pathway: CDC42 signaling events, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-extracellular matrix interactions, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem
• Function: GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; protein binding