"CAPN10" Related Products


Recombinant Human CAPN10 cell lysate

Cat.No.: CAPN10-276HCL
Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: CAPN10 calpain 10 [ Homo sapiens ]
Official Symbol: CAPN10
Synonyms: CAPN10; calpain 10; calpain-10; calpain-like protease CAPN10; calcium-activated neutral proteinase 10; CANP10; NIDDM1;
Gene ID: 11132
mRNA Refseq: NM_023083
Protein Refseq: NP_075571
MIM: 605286
UniProt ID: Q9HC96
Chromosome Location: 2q37.3
Pathway: Integrin-mediated cell adhesion, organism-specific biosystem;
Function: SNARE binding; calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; peptidase activity;

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