Recombinant Human CAPN10 cell lysate

• Cat.No.: CAPN10-276HCL

Specification

• Description: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: CAPN10 calpain 10 [ Homo sapiens ]
• Official Symbol: CAPN10
• Synonyms: CAPN10; calpain 10; calpain-10; calpain-like protease CAPN10; calcium-activated neutral proteinase 10; CANP10; NIDDM1
• Gene ID: 11132
• mRNA Refseq: NM_023083
• Protein Refseq: NP_075571
• MIM: 605286
• UniProt ID: Q9HC96
• Chromosome Location: 2q37.3
• Pathway: Integrin-mediated cell adhesion, organism-specific biosystem
• Function: SNARE binding; calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; peptidase activity