Recombinant Human CARD14 cell lysate

• Cat.No.: CARD14-282HCL

Specification

• Description: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: CARD14 caspase recruitment domain family, member 14 [ Homo sapiens ]
• Official Symbol: CARD14
• Synonyms: CARD14; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14; BIMP2; CARMA2; carma 2; card-maguk protein 2; CARD-containing MAGUK protein 2; bcl10-interacting maguk protein 2; FLJ38097
• Gene ID: 79092
• mRNA Refseq: NM_001257970
• Protein Refseq: NP_001244899
• MIM: 607211
• UniProt ID: Q9BXL6
• Chromosome Location: 17q25
• Function: CARD domain binding