Recombinant Human CARD8 cell lysate

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Recombinant Human CARD8 cell lysate

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Cat.No. : CARD8-283HCL
Description : The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene, but their biological validity has not been determined.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : CARD8 caspase recruitment domain family, member 8 [ Homo sapiens ]
Official Symbol : CARD8
Synonyms : CARD8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; CARDINAL; Dakar; KIAA0955; NDPP; TUCAN; apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine; DACAR; DAKAR; NDPP1; FLJ18119; FLJ18121; MGC57162; DKFZp779L0366;
Gene ID : 22900
mRNA Refseq : NM_001184900
Protein Refseq : NP_001171829
MIM : 609051
UniProt ID : Q9Y2G2
Chromosome Location : 19q13.33
Pathway : NOD-like receptor signaling pathway, organism-specific biosystem; NOD-like receptor signaling pathway, conserved biosystem;
Function : NACHT domain binding; cysteine-type endopeptidase activator activity involved in apoptotic process; protein binding; protein homodimerization activity;

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