Recombinant Human COBRA1 cell lysate

• Cat.No.: COBRA1-377HCL

Specification

• Description: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: COBRA1 cofactor of BRCA1 [ Homo sapiens ]
• Official Symbol: COBRA1
• Synonyms: COBRA1; cofactor of BRCA1; negative elongation factor B; KIAA1182; NELF B; negative elongation factor protein B; NELFB; NELF-B; RP13-122B23.3; DKFZp586B0519
• Gene ID: 25920
• mRNA Refseq: NM_015456
• Protein Refseq: NP_056271
• MIM: 611180
• UniProt ID: Q8WX92
• Chromosome Location: 9q34
• Pathway: Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; Disease, organism-specific biosystem; Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specific biosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat, organism-specific biosystem; Formation of RNA Pol II elongation complex, organism-specific biosystem; Formation of the Early Elongation Complex, organism-specific biosystem; Formation of the HIV-1 Early Elongation Complex, organism-specific biosystem
• Function: protein binding