Recombinant Human DPH5 cell lysate

• Cat.No.: DPH5-507HCL

Specification

• Species: Human
• Tag: Non
• Description: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: DPH5 DPH5 homolog (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: DPH5
• Synonyms: DPH5; DPH5 homolog (S. cerevisiae); diphthine synthase; CGI 30; protein x 0011; diphthamide biosynthesis methyltransferase; AD-018; CGI-30; NPD015; HSPC143; MGC61450
• Gene ID: 51611
• mRNA Refseq: NM_001077394
• Protein Refseq: NP_001070862
• MIM: 611075
• UniProt ID: Q9H2P9
• Chromosome Location: 1p21.2
• Pathway: diphthamide biosynthesis, organism-specific biosystem
• Function: diphthine synthase activity; diphthine synthase activity; methyltransferase activity; transferase activity