Recombinant Human DPH5 cell lysate
- Specification
- Gene Information
- Related Products
| Description : |
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Species : |
Human |
| Size : |
100 ul |
| Storage Buffer : |
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
| Applications : |
Western Blot; |
| Gene Name : |
DPH5 DPH5 homolog (S. cerevisiae) [ Homo sapiens ] |
| Official Symbol : |
DPH5 |
| Synonyms : |
DPH5; DPH5 homolog (S. cerevisiae); diphthine synthase; CGI 30; protein x 0011; diphthamide biosynthesis methyltransferase; AD-018; CGI-30; NPD015; HSPC143; MGC61450; |
| Gene ID : |
51611 |
| mRNA Refseq : |
NM_001077394 |
| Protein Refseq : |
NP_001070862 |
| MIM : |
611075 |
| UniProt ID : |
Q9H2P9 |
| Chromosome Location : |
1p21.2 |
| Pathway : |
diphthamide biosynthesis, organism-specific biosystem; |
| Function : |
diphthine synthase activity; diphthine synthase activity; methyltransferase activity; transferase activity; |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
