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Recombinant Human DPH5 cell lysate

Cat.No.: DPH5-507HCL
Description: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
Species: Human
Size: 100 ul
Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications: Western Blot;
Gene Name: DPH5 DPH5 homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol: DPH5
Synonyms: DPH5; DPH5 homolog (S. cerevisiae); diphthine synthase; CGI 30; protein x 0011; diphthamide biosynthesis methyltransferase; AD-018; CGI-30; NPD015; HSPC143; MGC61450;
Gene ID: 51611
mRNA Refseq: NM_001077394
Protein Refseq: NP_001070862
MIM: 611075
UniProt ID: Q9H2P9
Chromosome Location: 1p21.2
Pathway: diphthamide biosynthesis, organism-specific biosystem;
Function: diphthine synthase activity; diphthine synthase activity; methyltransferase activity; transferase activity;

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