Recombinant Human GLCE cell lysate

• Cat.No.: GLCE-709HCL

Specification

• Description: Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: GLCE glucuronic acid epimerase [ Homo sapiens ]
• Official Symbol: GLCE
• Synonyms: GLCE; glucuronic acid epimerase; D glucuronyl C5 epimerase , UDP glucuronic acid epimerase; D-glucuronyl C5-epimerase; heparan sulfate epimerase; HSEPI; KIAA0836; glucuronyl C5-epimerase; UDP-glucuronic acid epimerase; heparin/heparan sulfate-glucuronic acid C5-epimerase; heparin/heparan sulfate:glucuronic acid C5-epimerase
• Gene ID: 26035
• mRNA Refseq: NM_015554
• Protein Refseq: NP_056369
• MIM: 612134
• UniProt ID: O94923
• Chromosome Location: 15q23
• Pathway: Glycosaminoglycan biosynthesis - heparan sulfate, organism-specific biosystem; Glycosaminoglycan biosynthesis - heparan sulfate, conserved biosystem; Glycosaminoglycan biosynthesis, heparan sulfate backbone, organism-specific biosystem; Glycosaminoglycan biosynthesis, heparan sulfate backbone, conserved biosystem; Metabolic pathways, organism-specific biosystem; heparan sulfate biosynthesis, organism-specific biosystem; heparan sulfate biosynthesis, conserved biosystem
• Function: UDP-glucuronate 5-epimerase activity; isomerase activity; racemase and epimerase activity, acting on carbohydrates and derivatives