Recombinant Human HMGCR cell lysate

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Recombinant Human HMGCR cell lysate

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Cat.No. : HMGCR-802HCL
Description : HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Species : Human
Size : 100 ul
Storage Buffer : 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Applications : Western Blot;
Gene Name : HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ Homo sapiens ]
Official Symbol : HMGCR
Synonyms : HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; 3 hydroxy 3 methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl CoA reductase; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); LDLCQ3;
Gene ID : 3156
mRNA Refseq : NM_000859
Protein Refseq : NP_000850
UniProt ID : P04035
Chromosome Location : 5q13.3-q14
Pathway : Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, organism-specific biosystem; C5 isoprenoid biosynthesis, mevalonate pathway, conserved biosystem; Cholesterol Biosynthesis, organism-specific biosystem; Cholesterol biosynthesis, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem;
Function : NADP binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; oxidoreductase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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